Building energy use accounts for almost 50% of the total CO 2 emissions in the UK. Most of the research has focused on reducing the operational impact of buildings, however in recent years many studies have indicated the significance of embodied energy in different building types. This paper primarily focuses on illustrating the relative importance of operational and embodied energy in a flexible use light distribution warehouse. The building is chosen for the study as it is relatively easy to model and represents many distribution centres and industrial warehouses in Europe.A carbon footprinting study was carried out by conducting an inventory of the major installed materials with potentially significant carbon impact and material substitutions covering the building structure. Ecotect computer simulation program was used to determine the energy consumption for the 25 years design life of the building. This paper evaluates alternative design strategies for the envelope of the building and their effects on the whole life emissions by investigating both embodied and operational implications of changing the envelope
This paper illustrates the role of strawbale as a construction material and using strawbale load bearing construction technique in reducing the whole life impacts of housing by modelling the performance in CO 2 emissions of this method of construction. A detailed analysis has been carried out to investigate the potential of strawbale through analysis of embodied and operational CO 2 emissions in the Waddington social housing project recently completed in Lincolnshire in the UK by comparing some alternative domestic external wall constructions and the effects on the CO 2 emissions that would result.It is estimated that over fifteen tonnes of CO 2 may be stored in biotic materials of each of the semi detached houses of which around six tonnes are sequestered by straw and the remaining by wood and wood products. Our analysis indicate that the carbon lockup potential of renewable materials used in the construction of the house is capable of reducing the whole life CO 2 emissions of the house over its sixty years design life by 61% compared with the case without sequestration.The paper also discusses the practical implications of construction, detailing, maintenance, cost and selfbuild potentials of strawbale construction. The paper concludes by demonstrating the potential of loadbearing strawbale walls and 4 compares the whole life performance of strawbale construction with alternative conventional external walling systems..
Fluoride is a chemical element that is found most frequently in groundwater and has become one of the most important toxicological environmental hazards globally. The occurrence of fluoride in groundwater is due to weathering and leaching of fluoride-bearing minerals from rocks and sediments. Fluoride when ingested in small quantities (<0.5 mg/L) is beneficial in promoting dental health by reducing dental caries, whereas higher concentrations (>1.5 mg/L) may cause fluorosis. It is estimated that about 200 million people, from among 25 nations the world over, may suffer from fluorosis and the causes have been ascribed to fluoride contamination in groundwater including India. High fluoride occurrence in groundwaters is expected from sodium bicarbonate-type water, which is calcium deficient. The alkalinity of water also helps in mobilizing fluoride from fluorite (CaF2). Fluoride exposure in humans is related to (1) fluoride concentration in drinking water, (2) duration of consumption, and (3) climate of the area. In hotter climates where water consumption is greater, exposure doses of fluoride need to be modified based on mean fluoride intake. Various cost-effective and simple procedures for water defluoridation techniques are already known, but the benefits of such techniques have not reached the rural affected population due to limitations. Therefore, there is a need to develop workable strategies to provide fluoride-safe drinking water to rural communities. The study investigated the geochemistry and occurrence of fluoride and its contamination in groundwater, human exposure, various adverse health effects, and possible remedial measures from fluoride toxicity effects.
Recent changes in medical education have highlighted the importance of experiential learning. Simulation is one model that has gained significant attention in the last decade and has been widely adopted as a training and assessment tool in medical education. Pediatric simulation has been utilized to teach various skills including resuscitation and trauma management, procedural skills, and team training. It is also a valuable tool for health care educators, as it allows learners to achieve competence without putting patients at risk. Recent literature demonstrates increased retention of knowledge and skills after simulation-based training. Further research is required to improve current simulation curriculums, develop validated assessment tools, and to demonstrate improved clinical outcomes after simulation-based training. We conducted an online search of original and review articles related to simulation and pediatric medical education and provide an overview of the role and utility of simulation in pediatrics.Key PointsSimulation in pediatrics has been widely accepted and adapted as a training and assessment tool in medical education.Simulation in pediatrics has been utilized to teach various skills including resuscitation and trauma management, procedural skills, and team training.Further research is required to improve current simulation curriculums, to develop validated assessment tools, and to demonstrate improved clinical outcomes after simulation-based training.
Germ line mutations in BRCA2 gene predispose women to early-onset familial breast and ovarian cancer. BRCA2 is a protein of multiple functions. In addition to its role in DNA double-strand break repair, BRCA2 also plays a role in stabilization of stalled DNA replication forks, cytokinesis, transcription regulation, mammalian gametogenesis, centrosome duplication, and suppression of cell proliferation. However, how BRCA2 mutations predispose women specifically to breast and ovarian cancer remains undefined. Here we found that BRCA2 binds and stabilizes MAGE-D1, a member of the MAGE gene family of proteins. Expression of BRCA2 and MAGE-D1 synergistically suppresses cell proliferation independently of the p53 pathway. Using two MAGE-D1 RNA interferences and two cell lines expressing low or undetectable levels of MAGE-D1, we further showed that the expression of MAGE-D1 is required for BRCA2-mediated suppression of cell proliferation, indicating that MAGE-D1 is a downstream target of BRCA2 and that BRCA2 suppresses cell proliferation via stabilizing MAGE-D1. Importantly, MAGE-D1 protein expression was reduced in 6 of 16 breast carcinoma cell lines tested as compared with untransformed immortal mammary epithelial cell lines, suggesting that suppression of MAGE-D1 expression may be involved in the tumorigenesis of a subset of sporadic breast cancers. (Cancer Res 2005; 65(11): 4747-53)
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