Anthocephalus cadamba (Roxb.) Miq. Syn A. chinensis (Lamk) A. Rich (Rubiaceae) is ethnomedicinally widely used in the form of paste by tribe in western Ghats for treating skin diseases. In this context, antimicrobial potential of A. cadamba against a wide range of microorganisms was studied. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied, besides antioxidant activity to understand the mechanism of wound healing. The alchoholic and aqueous extract of this plant showed significant antibacterial and antifungal activity against almost all the organisms: Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and four fungi Candida albicans, Trichophyton rubrum-dermatophyte fungi, Aspergillus niger, Aspergillus flavus and Aspergillus nidulans-systemic fungi, with especially good activity against the dermatophyte (Trichophyton rubrum) and some infectious bacteria (Escherichia coli, Proteus mirabilis and Staphylococcus aureus) with an MIC of 2.5 µg/disc. The results show that A. cadamba extract has potent wound healing capacity as shown from the wound contraction and increased tensile strength. The results also indicated that A. cadamba extract possesses potent antioxidant activity by inhibiting lipid peroxidation and increase in the superoxide dismutase (SOD) and catalase activity.
Anthocephalus cadamba, an important plant in the traditional system of medicine in India, is reported to possess anticancer activity. Guided by bio-assay tests using human colorectal (HCT116) and hepatocellular carcinoma (HepG2) cell lines, it has been shown to contain three active constituents, the triterpenoid saponins 3- O-[α-L-rhamnopyranosyl]-quinovic acid (1) and 3- O-[α-L-rhamnopyranosyl]-quinovic acid 28- O-[β-D-glucopyranosyl] ester (2), and the alkaloid cadambine (3). The structures of the isolated compounds were established using spectroscopic techniques. The isolated compounds demonstrated concentration dependent inhibition of both the cell lines, where compound 3 proved to be the most potent inhibitor of cell line HCT116 (IC50 45 ± 4 μg/mL) and compound 2 demonstrated maximum inhibitory activity against HepG2 cell line with an IC50 value of 89 ± 7 μg/mL.
Ensuring high reliability and availability of draglines is imperative for the economic sustainability of a highly productive surface mining project. Draglines are very complex in design and consist of hundreds of components. Reliability modelling of a large complex system is difficult with conventional reliability analysis techniques. The dragging mechanism is a critical subsystem for the smooth operation of the draglines. This study uses the Bayesian Network (BN) model, mapped from the Fault Tree (FT), for the reliability analysis of Dragline. Sensitivity analysis identifies the critical components – helpful information for reliability management. The results demonstrate that three components of the dragging mechanism, namely, the drag motor system, drag brake and drag socket are primarily responsible for the poor reliability of the case study system. This study provides valuable information for maintenance planning of operating draglines and reliability blueprint of future dragline design.
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