This study demonstrated no statistical difference in pancreatic fistulae with the use of octreotide, though there was a trend towards fewer incidences of pancreatic fistulae, morbidity and shorter hospital stay. ClinicalTrials.gov Identifier: NCT01301222.
Aims:Even with the use of nerve-sparing techniques, there is a risk of bladder and sexual dysfunction after total mesorectal excision (TME). Laparoscopic TME is believed to improve this autonomic nerve dysfunction, but this is not demonstrated conclusively in the literature. In Indian patients generally, the stage at which the patients present is late and presumably the risk of autonomic nerve injury is more; however, there is no published data in this respect.Materials and Methods:This prospective study in male patients who underwent laparoscopic TME evaluated the bladder and sexual dysfunction using objective standardised scores, measuring residual urine and post-voided volume. The International Prostatic Symptom Score (IPSS) and International Index of Erectile Function score were used respectively to assess the bladder and sexual dysfunction preoperatively at 1, 3, 6 months and at 1 year.Results:Mean age of the study group was 58 years. After laparoscopic TME in male patients, the moderate to severe bladder dysfunction (IPSS <8) is observed in 20.4% of patients at 3 months, and at mean follow-up of 9.2 months, it was seen only in 2.9%. There is more bladder and sexual dysfunction in low rectal tumours compared to mid-rectal tumours. At 3 months, 75% had sexual dysfunction, 55% at median follow-up of the group at 9.2 months.Conclusion:After laparoscopic TME, bladder dysfunction is seen in one-fifth of the patients, which recovers in the next 6 months to 1 year. Sexual dysfunction is observed in 75% of patients immediately after TME which improves to 55% over 9.2 months.
Traumatic cysts of liver are amongst the less frequently known sequelae of liver trauma. The incidence of this entity is very low. We report a case of large posttraumatic liver cyst in a young adult female, who sustained blunt abdominal trauma 2 months back. The cyst was diagnosed by CECT Abdomen and was treated by hepatic resection(left lobe). The aim of presentation of this report is to highlight the fact that blunt trauma abdomen can result in such rare presentations which can lead to hepatic resection.
This mini-review centers on the framework of GQDs to function as a drug delivery system (DDS), that is both target-specific and efficient. Researchers exploit GQDs for the unique pharmacokinetic properties they possess, that make them an ideal multi-functional drug delivery vehicle. We cannot enhance the therapeutic efficacy of drugs merely by focusing on drug delivery mechanisms. The conjugation of the drug with GQD allows more flexibility in controlling the kinetics and circulation time of drug in the body, the characteristic which is highly regarded in modern therapeutics. GQDs possess properties such as enhanced water solubility, lower cytotoxicity, tunable photoluminescence properties, larger specific surface area, large surface to volume ratio, and ease of surface functionalization, which make them highly effective drug molecular loading cores. Also, the review addresses the various methods of synthesis of GQDs, that include top-down and bottom-up approaches; top-down modes being more feasible and advantageous. The review touches on the various modes of GQD drug-loaded delivery- release systems (DDRS). The review also addresses the limitations associated with drug delivery using GQDs. Insufficient information about the translocation of GQDs limits their application in biomedical field and make it difficult for GQD-based carriers to pass clinical trials. Through this review, we look to summarize the important concepts of drug delivery using GQDs, and their biomedical applications and scope in nanomedicine in foreseeable future
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