The results of our study demonstrate that muscarinic receptors are present in the human ureter. A novel finding is the identification of relatively high levels of M5 by both ICC and RT-PCR.
The kinetics of oxidation of four vicinal diols, four nonvicinal diols, and one of their monoethers by pyridinium bromochromate (PBC) have been studied in dimethyl sulfoxide. The main product of oxidation is the corresponding hydroxyaldehyde. The reaction is first-order with respect to each the diol and PBC. The reaction is acid-catalyzed and the acid dependence has the form:The oxidation of [1,1,2,2-2 H 4 ]ethanediol exhibitedobs a primary kinetic isotope effect ( at ). The reaction has been studied in 19 k /k ϭ 6.70 298 K H D organic solvents including dimethyl sulfoxide and the solvent effect has been analyzed using multiparametric equations. The temperature dependence of the kinetic isotope effect indicates the presence of a symmetrical transition state in the rate-determining step. A suitable mechanism has been proposed.
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