CD49d and CysLTR1-coexpressing PMNs are present during symptoms of an acute viral respiratory tract infection in human subjects. Further study is needed to examine selective targeting of proatopic neutrophils as a potential therapeutic strategy to prevent development of postviral atopic airway disease.

The authors aim to determine if a history of traumatic brain injury (TBI) assessed before dementia onset is associated with a higher risk of neuropsychiatric symptoms after dementia onset. A population-based incident series of people with dementia were assessed for TBI prior to onset of dementia and for neuropsychiatric symptoms after the onset, using the Neuropsychiatric Inventory. Participants with predementia TBI were more likely to exhibit disinhibition (12.7% versus 5.4%, OR=2.8, p=0.02), but not other neuropsychiatric symptoms. Traumatic brain injury may increase the risk of disinhibition in patients with dementia.

The statements and opinions expressed in COVID-19 Curbside Consults are based on experience and the available literature as of the date posted. While we try to regularly update this content, any offered recommendations cannot be substituted for the clinical judgment of clinicians caring for individual patients.

No abstract

an increased diagnosis of atopic dermatitis (P 5 .007). The majority of these atopic dermatitis patients with positive results from SPTs at 1 year of age were sensitized to food (91.6%), most commonly eggs (83%). CONCLUSIONS. There is poor agreement between the results of SPTs and SSIgE tests in early childhood, particularly in testing for sensitivity to food allergens and in testing at a younger age; therefore, these 2 tests cannot be used interchangeably. At least 1 SPT with positive results for sensitivity to an aeroallergen or food allergen at 1 year of age was predictive of the occurrence of atopic dermatitis during the follow-up period lasting up to 6 years of age. REVIEWER COMMENTS. This birth cohort study is unique in that it evaluates for consistency between the results of SPTs and SSIgE levels over time in the early childhood population. Exploration in a more diverse population that is not limited to the rural setting and in a larger cohort would be beneficial because a low number of subjects in this study had positive SPT results. The poor correlation between SPT and SSIgE test results seen in this study provides additional insight regarding the development and natural course of sensitization in early childhood and suggests that correlation with clinical outcomes remains essential.

No abstract

No abstract

No abstract