The potential of tuber flour of Ipomoea batatas (L.) Lam. cv. Brazlândia Branca (white sweet potato) as wound healing and antiulcerogenic agent was investigated in vivo in animal model. Excision on the back of Wistar rats was performed to induce wounds that were topically treated with Beeler’s base containing tuber flour of white sweet potato at 2.5%. Number of cells undergoing metaphase and the degree of tissue re-epithelialization were investigated 4, 7 and 10 days post-treatment. The protective effect of aqueous suspension of tuber flour (75 and 100 mg/kg animal weight) on gastric mucosa of Wistar rats was also studied by using the ethanol-induced ulceration model. Ointment based on white sweet potato at 2.5% effectively triggered the healing of cutaneous wound as attested by the increased number of cells undergoing metaphase and tissue re-epithelialization regardless the time of wound treatment. Tuber flour potentially prevented ethanol-induced gastric ulceration by suppressing edema formation and partly protecting gastric mucosa wrinkles. Crude extracts also exhibited potential as free radical scavengers. The results from animal model experiments indicate the potential of tuber flour of white sweet potato to heal wounds.
The second-generation bioethanol employs lignocellulosic materials degraded by microbial cellulases in their production. The fungus Trichoderma reesei is one of the main microorganisms producing cellulases, and its genetic modification can lead to the optimization in obtaining hydrolytic enzymes. This work carried out the deletion of the sequence that encodes the zinc finger motif of the transcription factor ACE1 (cellulase expression repressor I) of the fungus T. reesei RUT-C30. The transformation of the RUT-C30 lineage was confirmed by amplification of the 989 bp fragment relative to the selection marker, and by the absence of the zinc finger region amplification in mutants, named T. reesei RUT-C30Δzface1. The production of cellulases by mutants was compared to RUT-C30 and measured with substrates carboxymethylcellulose (CMC), microcrystalline cellulose (Avicel ® ) and Whatman filter paper (PF). The results demonstrated that RUT-C30Δzface1 has cellulolytic activity increased 3.2-fold in Avicel and 2.1-fold in CMC and PF. The mutants presented 1.4-fold higher sugar released in the hydrolysis of the biomass HIGHLIGHTS Enhance of Trichoderma reesei RUT-C30∆zface1. Deletion of zinc finger of the repressor transcription factor cellulase ACE1. Optimized fungal strain for the production of cellulase. Greater efficiency in the enzymatic activity and sugarcane hydrolysis. 2 Dudek, D.N.; et al.
RESUMO:Rara a existência de um indivíduo que nunca apresentou ao longo de sua vida uma crise de cefaléia. Estima-se que a prevalência ao longo da vida na população seja superior a 90%. Vários estudos epidemiológicos de cefaléias são realizados com o objetivo de reconhecer e aprimorar suas características, auxiliando para o melhor entendimento fisiopatológico desta enfermidade. Estudos de prevalência sugerem fatores de risco sendo genéticos e sociodemográficos.O estudo realizado é do tipo survey descritivo, com a aplicação de um questionário a todos os funcionários do Hospital Missen e do Hospital psiquiátrico Cristo Redentor, ambos localizados na cidade de São Miguel d'Oeste, Santa Catarina. É sabido que as mais diversas populações são estudadas, mas colaboradores do ambiente hospitalar têm recebido pouca atenção; fazendo disso o objetivo para a realização deste trabalho. Com este estudo concluiu-se que a cefaléia na comunidade hospitalar foi marcante, com grande incidência em ambos os sexos e o estresse foi o fator desencadeante mais pronunciado, prejudicando o bem estar e a produtividade dos colaboradores. A implantação de medidas simples e baratas poderia melhorar a qualidade de vida bem como aumentar a produtividade destes funcionários. Palavras-chave: hospital, cefaléia, medicação e fatores desencadeantes ABSTRACT:Rare is the existence of an individual that has never presented through his entire life a headache crisis. It's estimated that the prevalence during all the life in the population be over 90%. Several epidemiological studies on headaches are performed with the intent of recognizing and enhancing their characteristics, helping a better phisiopathological understanding of this illness. Prevalence studies suggest risk factors as being genetical and sociodemographical. The study performed is a descriptive survey using a questionary applied to all employees of Missen Hospital and Cristo Redentor Psychiatric Hospital, both located in the city of São Miguel do Oeste, Santa Catarina. It's known that the most diverse populations are studied, but the community of hospital work has received little attention, so the accomplishment of this work shows a noble objective. With this study we've concluded that headaches in the hospital work environment were very marked with great incidence in both genders and the stress was the most pronunciated precipitating factor, harming the well-fare and productivity of the interviewed. The implantation of simple and cheap measures could improve the quality of life as well as increase the productivity of these employees.
RESUMO:Os inibidores da enzima conversora da angiotensina (ECA) têm alta eficácia no tratamento da pressão arterial elevada, bem como a ser utilizado em situações de insuficiência cardíaca. O mecanismo de ação desses medicamentos é fornecido pela inibição da formação de angiotensina II, um potente agente vasoconstritor, através do bloqueio da ECA. Os efeitos adversos mais comuns são: tosse, hipotensão ortostática na primeira dose, erupção cutânea, perda do paladar, proteinúria, leucopenia e hipersensibilidade com edema angioneurótico. O estudo realizado é a avaliação do efeito colateral dos inibidores da enzima conversora da angiotensina. Os resultados foram analisados através do programa Epi Info 3.3.2 de 9 de fevereiro de 2005. Entre os itens variáveis sócio-demográficas, o sexo feminino tem 71,7% da amostra, a média de idade de 53 anos e ensino fundamental incompleto 67,9% das pessoas entrevistadas. Em relação ao estado civil, 83,0% eram casados, quanto ao regime domiciliar 51,9% pertenciam à primeira geração (com um cônjuge), sendo 66,0% tem como renda mensal 1 (um) salário mínimo. Em relação as variáveis farmacoepidemiológicas alguns dos resultados encontrados foram, o medicamento de uso mais freqüente foi o inibidor da ECA (Captopril), prescrito para 67,9% dos hipertensos, com aparecimento de tosse em aproximadamente 3 a 20% dos pacientes. Com relação à adesão ao tratamento 86,8% respondem positivamente. Diante da realidade assinalada é necessário aumentar o grau de conhecimento da população sobre a importância do controle da hipertensão arterial, e a adesão à terapêutica cardiovascular. É necessário e urgente garantir acesso dos pacientes hipertensos a serviços básicos de saúde, e incentivar políticas e programas comunitários. O primeiro passo é a educação dos pacientes, seus familiares e a comunidade, onde uma equipe multiprofissional poderá fornecer aos pacientes e à comunidade motivação para vencer os desafios e adotar atitudes que tornem as ações efetivas e permanentes. Palavras-chave: Inibidores da enzima conversora da angiotensina, tosse, pressão arterial alta. ABSTRACT:The inhibitors of the converting enzyme of the angiotensin (ECA) have high effectiveness in the treatment of the high blood pressure, as well as being used in situations of heart failure. The mechanism of action of these drugs is provided by the inhibition of the formation of angiotensin II, a powerful vasoconstrictor agent, through the blockade of the ECA. The more common adverse effects are: cough, orthostatic hypotension of first dose, cutaneous eruption, loss of the palate, proteinuria, leucopenia and hypersensibility with angioneurotic edema. The study performed is a avaliated the collateral effect of inhibitors of the converting enzyme of the angiotensin. The results had been analyzed through the Epi Info 3.3.2 program of February 9th, 2005. Amongst the socialdemographic variable items, the feminine sex got 71.7% of the sample, average age of 53 years and incomplete basic education 67.9% of the interviewed people. In relation t...
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