Aims:The aim of present study was to evaluate Gum Katira obtained from the plant Cochlospermum religiosum (Family Cochlospermaceae) as a matrix forming pharmaceutical excipient for a novel drug delivery system. Materials and Methods: Gum Katira was used for the drug release retarding material in microsphere formulation using Etodolac as a model drug. Etodolac was found to be compatible with the matrix material Gum Katira by conducting the various physiochemical and instrumental analysis. Result: Etodolac loaded Gum Katira microsphere (ELGKM) was compared with Etodolac loaded sodium alginate microsphere (ELSAM) and blank microsphere (without gum matrix), which subsequently revealed that the drug release rate of ELGKM was better for sustained and controlled release. Conclusion: In our experiment, it was found that the drug release mechanism best fitted in Korsmeyers Peppas model on comparing the correlation coefficient values of different mathematical models. The result of this study indicates that ELGKM (1% w/v Gum Katira) would be desired formulations in delivering the drug with controlled and sustained release pattern.
Etodolac is a non-steroidal anti-inflammatory drug (NSAID) and approved by USFDA as a COX2 inhibitor. Although etodolac therapy provides clinical benefits, it is associated with upper gastrointestinal (GI) tract complications also. Etodolac loaded gum Katira microsphere (ELGKM) was prepared by W 1 /O/W 2 emulsion solvent evaporation technique. The gastric irritation properties of orally administered pure etodolac, ELGKM and blank microspheres (without etodolac) were evaluated in experimental rats treated for 6 days. The stomach examination and biochemical investigation of stomach tissue of treated rats indicated that ELGKM formulation remarkably reduced ulcerogenecity as compared to pure etodolac. The anti-inflammatory activities of pure etodolac and ELGKMs were ascertained by the implantation of cotton pellets in rats for 6 days. Based on the results, ELGKMs showed significant anti-inflammatory activities (P<0.01) as compared to control group. The cotton pellets test suggested that ELGKM formulation retained more anti-inflammatory properties among the groups. The hematological changes, biochemical analysis and histopathological studies of subacute toxicity in rats revealed that ELGKM were the effective sustained release formulation in the treatment of chronic pain and inflammation. In conclusion, the physicochemical characterization, pharmacological and toxicological studies suggest that ELGKMs may represent as a potential candidate for sustained drug delivery (10-12 hours) in chronic joint pain related diseases with remarkably diminished gastrointestinal side effects.
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