Developing and testing algorithms for autonomous vehicles in real world is an expensive and time consuming process. Also, in order to utilize recent advances in machine intelligence and deep learning we need to collect a large amount of annotated training data in a variety of conditions and environments. We present a new simulator built on Unreal Engine that offers physically and visually realistic simulations for both of these goals. Our simulator includes a physics engine that can operate at a high frequency for real-time hardware-in-the-loop (HITL) simulations with support for popular protocols (e.g. MavLink). The simulator is designed from the ground up to be extensible to accommodate new types of vehicles, hardware platforms and software protocols. In addition, the modular design enables various components to be easily usable independently in other projects. We demonstrate the simulator by first implementing a quadrotor as an autonomous vehicle and then experimentally comparing the software components with real-world flights.

Abstract-Autonomous navigation for large Unmanned Aerial Vehicles (UAVs) is fairly straight-forward, as expensive sensors and monitoring devices can be employed. In contrast, obstacle avoidance remains a challenging task for Micro Aerial Vehicles (MAVs) which operate at low altitude in cluttered environments. Unlike large vehicles, MAVs can only carry very light sensors, such as cameras, making autonomous navigation through obstacles much more challenging. In this paper, we describe a system that navigates a small quadrotor helicopter autonomously at low altitude through natural forest environments. Using only a single cheap camera to perceive the environment, we are able to maintain a constant velocity of up to 1.5m/s. Given a small set of human pilot demonstrations, we use recent state-of-theart imitation learning techniques to train a controller that can avoid trees by adapting the MAVs heading. We demonstrate the performance of our system in a more controlled environment indoors, and in real natural forest environments outdoors.

Drones equipped with cameras are emerging as a powerful tool for large-scale aerial 3D scanning, but existing automatic flight planners do not exploit all available information about the scene, and can therefore produce inaccurate and incomplete 3D models. We present an automatic method to generate drone trajectories, such that the imagery acquired during the flight will later produce a highfidelity 3D model. Our method uses a coarse estimate of the scene geometry to plan camera trajectories that: (1) cover the scene as thoroughly as possible; (2) encourage observations of scene geometry from a diverse set of viewing angles; (3) avoid obstacles; and (4) respect a user-specified flight time budget. Our method relies on a mathematical model of scene coverage that exhibits an intuitive diminishing returns property known as submodularity. We leverage this property extensively to design a trajectory planning algorithm that reasons globally about the non-additive coverage reward obtained across a trajectory, jointly with the cost of traveling between views. We evaluate our method by using it to scan three large outdoor scenes, and we perform a quantitative evaluation using a photorealistic video game simulator.

This paper demonstrates the feasibility of recovering fine-scale plant structure in 3D point clouds by leveraging recent advances in structure from motion and 3D point cloud segmentation techniques. The proposed pipeline is designed to be applicable to a broad variety of agricultural crops. A particular agricultural application is described, motivated by the need to estimate crop yield during the growing season. The structure of grapevines is classified into leaves, branches, and fruit using a combination of shape and color features, smoothed using a conditional random field (CRF). Our experiments show a classification accuracy (AUC) of 0.98 for grapes prior to ripening (while still green) and 0.96 for grapes during ripening (changing color), significantly improving over the baseline performance achieved using established methods.

Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby causing insulin resistance and type 2 diabetes. However, the underlying mechanism involved is still unclear. In searching for the cause of the mechanism, it has been found that palmitate inhibits insulin receptor (IR) gene expression, leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKCε causes this reduction in insulin receptor gene expression. One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies. We provide an overview of this important area, emphasizing the current status. Abbreviations used: IDDM, insulin-dependent diabetes mellitus; NIDDM, non-insulin dependent diabetes mellitus; IR, insulin receptor; FFA, free fatty acid; IRS, insulin receptor substrate; PI3 kinase, phosphatidylinositol 3 phosphate kinase; PIP 2 , phosphatidylinositol 4,5 bisphosphate, DAG; diacylglycerol; PDK1, phosphoinositide-dependent kinase-1.