Recently, an article by Askow et al. (2022) was published ahead of print in the journal on August 25, 2022. Researchers in this study recruited 29 participants and had them consume 5 g/day of either creatine monohydrate (CM), creatyl-l-leucine (CLL), or a placebo for 14 days in a randomized, double-blind design. During this time, participants also performed three resistance training sessions per week. Muscle creatine content was quantified via muscle biopsies pre-and postintervention. The authors reported that CM supplementation significantly increased muscle creatine content within 14 days of supplementation, but no significant changes in muscle creatine content were observed for the placebo or CLL groups.This letter will highlight a critical flaw in the design of the study, draw attention to other study limitations or inconsistencies, and point to a calculation error in the discussion. It will also Escalante
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