Introduction: The evidence of transplancental transmission of Morbus Hansen (MH) in animal models is a challenge for MH treatment in pregnancy because it brings anxiety for patients and their fetuses. Case: A 31-year-old pregnant woman, first trimester, came with complaints of reddish numbness rash on her hands since 2 years ago. Dermatological examination showed erythematous plaque, multiple, well-defined, irregular borders with hypoaesthesia. There were right and left ulnar nerve enlargement. Acid Fast Bacteria (AFB) from ear lobes and lesion revealed Bacterial Index +2 and Morphological Index 10%. Histopathological examination showed gren zone which indicate MH type BL. Patient was diagnosed with MH Multi Basiler (MB) on G3P2002Ab000 and given MDT MHMB. Postpartum IgM and IgG anti-PGL-1 examination of cord blood and infant blood, also PCR examination of cord blood and amnion showed negative results. Histopathological examination found no AFB on the umbilical cord and placenta. Conclusion: MDT is effective in preventing transplacental transmission of MH from mother to fetus.
Background: Condylomata accuminata is a sexually transmitted disease, appeared as verrucous or cauliflower-like papules or warts in the anogenital. It is caused by human papillomavirus (HPV), mostly type 6 and 11. The ideal therapy should be simple, inexpensive, effective, does not cause side effects, and can be used by the patient himself. Purpose: To assess the effectiveness of 5-Fluorouracil (5-FU) 5% cream therapy for perianal condylomata accuminata treatment. Case: A 24-year-old male presented with a chief complaint of warts around the anal area that multiplied in the past 3 weeks. The acetowhite test was positive. The patient was diagnosed with condylomata accuminata perianal. The patient received 5-FU 5% cream, applied 3 times a week to the lesions for 5 weeks. After 5 weeks, no new warts were found. Discussion: 5-FU 5% cream is a therapeutic option for perianal wart lesions that easily applied, inexpensive, effective, does not cause side effects, and can be used by the patient himself. It is well known as an antimetabolite with a cytotoxic effect that occurs through a mechanism of disruption in the normal synthesis and function of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The treatment with 5-FU 5% cream 3 times a week for 5 weeks provided good results with no side effects were reported. Conclusion: The application of 5-FU 5% cream was a modality of self-application treatment that effective for perianal condylomata accuminata.
Skin photoaging is cumulative skin damage due to chronic environmental exposure, especially ultraviolet (UV) light, which interferes with the keratinocyte and fibroblast syntheses by matrix metalloproteinases (MMP). Retinol can improve wrinkles, pigmentation, elasticity, firmness, brightness, and various signs of photoaging on the skin. Astaxanthin is a powerful antioxidant that protects the skin from UV rays, inhibits MMP, and stimulates collagen production. This case report presents 2 cases of women complaining about deep skin wrinkles, dullness, and looseness. Physical examination in the facial region revealed wrinkles when resting in the first patient and wrinkles during motion in the second patient. The first patient was diagnosed Glogau III photoaging, while the second patient was diagnosed Glogau II photoaging. Both patients received astaxanthin gel therapy and SPF 33 sunscreen cream every morning, as well as 0.1% retinol serum every night. There was an improvement after six weeks. Astaxanthin and retinol 0.1% can be used as photoaging therapy. Adequate use of photoprotection is also necessary to prevent the worsening of photoaging.
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