Background: Class Ib ribonucleotide reductase (RNR) is an essential enzyme for aerobic growth of S. sanguinis. Results: Its manganese form is 3.5-fold more active than the iron form when assayed with NrdH and thioredoxin reductase. Conclusion: This specific activity is the highest reported to date for the class Ib RNR. Significance: Our studies suggest why manganese is important in streptococcal pathogenesis.
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