BackgroundFirst-line maintenance erlotinib in patients with locally advanced or metastatic nonsmall cell lung cancer (NSCLC) has demonstrated significant overall survival and progression-free survival benefits compared with best supportive care plus placebo, irrespective of epidermal growth factor receptor (EGFR) status (SATURN trial). The cost-effectiveness of first-line maintenance erlotinib in the overall SATURN population has been assessed and published recently, but analyses according to EGFR mutation status have not been performed yet, which was the rationale for assessing the cost-effectiveness of first-line maintenance erlotinib specifically in EGFR wild-type metastatic NSCLC.MethodsThe incremental cost per life-year gained of first-line maintenance erlotinib compared with best supportive care in patients with EGFR wild-type stable metastatic NSCLC was assessed for five European countries (the United Kingdom, Germany, France, Spain, and Italy) with an area-under-the-curve model consisting of three health states (progression-free survival, progressive disease, death). Log-logistic survival functions were fitted to Phase III patient-level data (SATURN) to model progression-free survival and overall survival. The first-line maintenance erlotinib therapy cost (modeled for time to treatment cessation), medication cost in later lines, and cost for the treatment of adverse events were included. Deterministic and probabilistic sensitivity analyses using Monte Carlo simulation (1000 iterations) were performed.ResultsAccording to the model simulations, first-line maintenance erlotinib compared with best supportive care in EGFR wild-type stable metastatic NSCLC resulted in 4.57 months of life gained (17.82 months for erlotinib versus 13.24 months for best supportive care) and 1.14 months of life without progression gained (erlotinib 4.29 versus best supportive care 3.15), and incremental total costs of erlotinib from €7897 (UK) to €9580 (Germany). The corresponding mean incremental cost per life-year gained of erlotinib ranged between €20,711 (UK) and €25,124 (Germany). Sensitivity analyses confirmed these results.ConclusionFirst-line erlotinib maintenance treatment is cost-effective compared with best supportive care in EGFR wild-type stable metastatic NSCLC, irrespective of the country setting.
Small angle X-ray scattering (SAXS) is a powerful technique for the characterization of systems with highly ordered structures, such as liquid crystals and self-assembly systems. In the field of nanotechnology and nanomedicine, SAXS can be used to characterize the crystallographic properties -namely, the space group symmetry and lattice parameter -of the crystal phase of lyotropic systems and nanoparticles with internal crystal phase, such as cubosomes, hexosomes and multi-lamellar vesicles. In this work, we introduce a new web platform named: Small Angle Scattering Crystallographic Peak Treatment and Analysis (SCryPTA), capable of reading SAXS data and providing a comprehensive visualization of the scattering curve along with the calculation of important physical parameters, such as the lattice parameter of the crystal structure, the lipidic bilayer width, among others. Cubic, hexagonal and multilamellar scattering data had their crystallographic structure characterized in SCryPTA. So far, four different cubic structures, (Pn3m (Q224), Fd3m (Q227), Im3m (Q229), Ia3d (Q230)), the hexagonal phase and also multi-lamellar vesicle systems are described in the software. We believe that SCryPTA may help researchers from several fields, since it has a user-friendly interface.
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