objeCtives: To assess the relative efficacy and safety of canagliflozin (CANA), a sodium-glucose co-transporter inhibitor, as an add-on to MET+SU, versus DPP-4 inhibitors, GLP-1 agonists and insulin, using Bayesian network meta-analysis (NMA). Methods: A systematic literature review was conducted according to NICE guidelines. Outcomes of interest included HbA1c, weight and hypoglycaemia.
number of published studies on "cost effectiveness" have increased by more than 30%. There is a large variability in CERs for same drugs for different indications, in some cases also varying by biomarkers. Primary care drugs had lower and less variable CERs than specialty drugs. Variations also exist in methodology used by different groups in modeling cost effectiveness, especially for time horizon and comparator. Majority of primary care drugs were modeled for a time horizon of 35-40 years or lifetime to demonstrate cost effectiveness. CONCLUSIONS: This analysis shows the range, variability and methods used for calculation of ICER values for these high budget impact drugs and provides lessons for executives and policy makers.
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