Examination under anaesthesia showed the comeae to be normal (diameter 10 mm. each eye). The ocular tension was 4 5 mm. Hg (Schi0tz) with the 5 5 gm. weight in each eye. Gonioscopy showed that only a small rim of iris tissue was present. The lenses appeared smaller than normal. Fundus examination showed a temporal crescent at both discs. There was a small hypermetropic refractive error in both eyes.There were two healthy sibs aged 18 months and 6 months. There was no family history of any form of eye anomaly.On admission the aniridia was confirmed (Fig. 1, opposite), and a large mass diagnosed clinically as Wilms's tumour (Fig. 2, opposite) was palpable on the right side of the abdomen. An intravenous pyelogram showed a large mass in the right kidney distorting the normal calyceal pattern and there was also evidence of a smaller mass in the left kidney.Pre-operative blood transfusion was necessary, a course of actinomycin-D was started, and at operation (Mr. J. Grieve) a large renal tumour was found on the right side. The inferior vena cava was blocked by local spread of the tumour. The left kidney was palpated at operation but no abnormality was found. A right nephrectomy was undertaken and the vena cava cleared by a Fogarty catheter. Microscopy confirmed that the tumour was a nephroblastoma.After the operation she was at first reasonably well but her clinical condition slowly deteriorated and despite intensive therapy she developed broncho-pneumonia and died.Post-mortem Examination (Dr. Mehroo Forbes).-This confirmed the broncho-pneumonia, and in the left kidney a mass 3 5 cm. in diameter was discovered which on microscopy was also shown to be a nephroblastoma. No metastases were found in any other organ.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.