Background:The melanocortin 1 receptor is known to regulate inflammation. Results: The melanocortin 1 receptor inhibits activation of p38 MAPK, subsequently enhancing syndecan-2 expression and migration in melanoma cells.
Conclusion:The melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression. Significance: This work shows the melanocortin 1 receptor plays a role during cell migration.
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