There was a two-fold or greater increase in the activity of sulfisoxazole against S. pyogenes 4 in combination with 3a-d (2.1-, 3.8-, 2.6-, and 6.2-fold, respectively); against D. pneumoniae 6301 in combination with 3b,c,e (2.1-, 2.1-, and 3.8-fold, respectively); against S. aureus 209 in combination with 3a-e (>5.0-, 4.0-, >3.5-, 2.5-, and >11.0-fold, respectively); against E. coli 257 in combination with 3a-e (2.0-, 5.7-, 4.7-, 2.5-, and >8.9-fold, respectively); against K. pneumoniae KA in combination with 3b and 3e (3.1-, and 4.1-fold, respectively); against P. vulgaris 190 in combination with 3a,b,c,e (2.3-, 2.6-, 11.1-, and 9.2-fold, respectively); in combination with 3b and 3e against S. typhosa P58a (11.0-and 4.0-fold, respectively) and in combination with 3b against S. schottmuelleri (5.4-fold). No potentiation of sulfisoxazole was observed with any compound against P. aeruginosa. These results are summarized in Table III.
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