Transtorine (1), a new quinoline alkaloid, isolated from the aerial part of Ephedra transitoria by column chromatography, was identified as 4-quinolone-2-carboxylic acid. The structure was determined by spectroscopic methods. Transtorine exhibited growth inhibitory activity against the common bacteria, Enterobacter cloacae, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.
Page 262: The authors wish to withdraw from the literature the trivial name "transitorine". This alkaloid is not of novel structure, since it represents an already known tautomer of kynurenic acid. The 4-keto tautomer of kynurenic acid is the preferred form in polar solvents (e.g., DMSO-d 6 , as used to determine the NMR spectra of "transitorine") (Leeson, P. D.; Baker, R.; Carling, R. W.; Curtis, N. R.; Moore, K. W.; Williams, B. J.; Foster, A. C.; Donald, A. E.; Kemp, J. A.; Marshall, G. R.
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