Research question and the most important issue in this paper relates to the determination of CO2 emission drivers in EU and the possibility of its reduction in the era of the fourth industrial revolution. EU strategies and economic policies are directed toward sustainable development, with special emphasis on reducing CO2 emissions towards carbon neutrality. The method used in this research is the Panel Generalized Method of Moments (GMM) two-step dynamic estimator on 27 EU countries in the period 2012–2019. The research resulted with the following findings: innovation activity, industrial structure and development, human capital, and institutional framework; these are all statistically associated with CO2 emission levels in a negative manner, thus, contribute significantly to the reduction in CO2 emissions. Following the empirical results, it may be concluded that reaching sustainable development goals requires the EU to enhance innovation activity, technological development, reshape its industrial structure, create high-quality human capital, and increase the quality of its public institutions.
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