Polyalanine expansions in two of three large imperfect trinucleotide repeats encoded by the first exon of HOXA13 have been reported in hand-foot-genital syndrome (HFGS). Here we report additional families with expansions in the third repeat of 11 and 12 alanine residues, the latter being the largest expansion reported. We also report a patient with a novel, de novo 8-alanine expansion in the first large repeat. Thus, expansions in all three large HOXA13 polyalanine repeats can cause HFGS. To determine the molecular basis for impaired HOXA13 function, we performed homologous recombination in ES cells in mice to expand the size of the third largest polyalanine tract by 10 residues (HOXA13(ALA28)). Mutant mice were indistinguishable from Hoxa13 null mice. Mutant limb buds had normal steady-state Hoxa13 RNA expression, normal mRNA splicing and reduced levels of steady-state protein. In vitro translation efficiency of the HOXA13(ALA28) protein was normal. Thus, loss of function is secondary to a reduction in the in vivo abundance of the expanded protein likely due to degradation.

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The aim of the paper is to test the impact of various potential causes of unofficial economy in new member states (NMS). The hypothesis of the paper is that the most significant factors in NMS are the tax burden and the overall institutional environment. Paper uses unofficial economy estimates based on MIMIC and exhaustiveness of national account approaches over a longer period. A panel data method is used in econometric models in which various indicators of the intensity of regulations, tax burden, institutional framework and labour market conditions are used as potential factors able to explain cross-country differences in the sizes and trends in the unofficial economies. ARTICLE INFO

Over the past two decades, the issue of regional convergence in the European Union has been the subject of a wide range of empirical research. This paper aims to provide more information on the differences in regional growth patterns of new member states (NMS), as well as Croatia, in addition to the factors influencing regional disparities within each country. This research provides an analysis of regional convergence in the period 2001-2008 at the NUTS II and NUTS III level. The most widely used model for testing convergence hypotheses is beta-convergence analysis. Other factors commonly included in the econometric modelling of convergence are demographic variables, labour market conditions, industrial structure, institutional factors and overall government policy. The main hypothesis is that the process of regional convergence in NMS and Croatia is not strong enough to dominate over other factors, influencing regional potential growth (mainly industry structure and quality of human capital). Absolute β-convergence can be found at the national level for EU countries. Convergence also can be found for NMS regions, but the pace of convergence on the regional level is lower in comparison to the national level and the estimated β-convergence parameter is less significant.

The article quantifies the sources of manufacturing export growth in Croatia. The research objectives are achieved by applying the constant market share method (C.M.S.) and input-output model. While the C.M.S. method quantifies the factors which explain trends in manufacturing exports, the input-output method quantifies the impacts of manufacturing exports on other domestic sectors. The obtained results show that after the E.U. accession export performance of the Croatian manufacturing industry have substantially improved. The results indicate that a gain in competitiveness in the Croatian manufacturing industry was the most important factor which determined the increasing share of national companies in a period from 2013 to 2015. Besides the manufacturing industry, export growth indirectly contributes to better performance of all domestic producers included in the value added chain of exporters. Indirect effects are the most pronounced for agriculture, trade, transport and business services.

The goal of this article is to provide a deeper insight to the overall contribution of the export of food products to the Croatian economy and to estimate the direct and indirect impact of the international competitiveness of food producers on other domestic sectors. The authors measure the importance of the food sector by employing both the constant market share (CMS) and the input-output analysis. The results indicate that a loss in competitiveness in the Croatian food industry was the most important factor that determined the decreasing share of national companies in the period from 2009, when the global recession started, up to 2013, when Croatia joined the EU. EU membership strongly and positively influenced the performance of Croatian food exports. The negative trend regarding the share of the international food market was reversed. Besides having a direct impact on the export performance of the food industry, the international competitiveness of food producers indirectly affects other domestic companies whose products are used as intermediate inputs in the food industry. The study also presents a benchmark of results with previous research for EU countries, which rarely included Croatia before the accession in 2013. As far as output and value added are concerned, multipliers for the food industry are relatively significant and higher than the national average, and the food industry could be assessed as one of the key Croatian economic sectors.

This paper tests the hypothesis that incentives for renewable energy sources contribute to economic development in Croatia. The aim of the paper is to quantify the total effects of wind power plant deployment on the Croatian economy in terms of employment and gross value. Indirect and induced effects are spread over the value added chain of producers of investment and intermediate goods and services required for wind power plant deployment and operation. The open input-output model is used for quantifying indirect effects. The closed input output model, which assumes endogenous personal consumption, is applied for quantifying total effects, which includes the effects of induced personal consumption. The gross value added and employment type I and type II multipliers related to wind power plants in Croatia were calculated separately for the investment and intermediate consumption channel. The results show positive indirect and induced effects relating to the deployment of wind power plants in Croatia. They are less pronounced in comparison to previous studies due to the undeveloped domestic production of equipment required for wind power plant deployment. Apart from the manufacturing sector, which produces equipment incorporated into wind power plants, the total effects were significant for construction, transport, and other supporting industries.