The role of the Cl– anion as a templating agent for the synthesis of cyclopeptides was
assessed through the preparation of three new homocyclolysines and
other six cyclic peptides by head-to-tail lactamization. Isolated
yields of products obtained by chloride-templating approach were considerably
higher than those gained by a cation-promoted procedure, whereby,
in some cases, only the anion-assisted synthesis yielded the desired
cyclopeptides.
cytokeratin 6 and 17. Ultimately, the overexpression of HGF in DPSCs improved the erythema, scaling, and hyperkeratinization associated with psoriatic lesions in a mouse model.DPSCs may also have the potential as an anti-aging treatment. According to Li et al., DPSCs, if co-cultured with skin fibroblasts, significantly decreased proliferation of the fibroblasts. 7 This reduction in dermal fibroblast proliferation appears to be mediated by effects on the cell cycle. Fibroblasts decreased in the G1 phase but increased in the S and G2 phases. In addition, fibroblasts co-cultured with DPSCs expressed increased amounts of pRb and decreased amounts of p53 and p21.Although DPSCs were first isolated nearly two decades ago, the potential therapeutic applications of these stem cells to cutaneous conditions have not been explored until recently.The aforementioned studies suggest that DPSCs may have clinical value in psoriasis treatment and anti-aging via immunomodulation and alteration of dermal fibroblasts, respectively. Additional studies of DPSCs are needed before human trials can begin, including additional research to determine the potential for harmful side effects. Therefore, the use of DPSCs in dermatological conditions remains in the nascent phases. In fact, the coming years may reveal additional novel applications of DPSCs to cutaneous disease.
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