Objective. To provide a current and comprehensive understanding of the cost-effectiveness of DMTs for the treatment of MS by quantitatively evaluating the quality of recent cost-effectiveness studies and exploring how the field has progressed from past recommendations. Methods. We assessed the quality of studies that met our systematic literature search criteria using the Quality of Health Economic Studies validated instrument. Results. Of the 82 studies that met our initial search criteria, we included 22 in this review. Four studies (18%) achieved quality category 2, three studies (14%) achieved quality category 3, and 15 studies (68%) achieved the highest quality category 4. 91% of studies were simulation models. 13 studies (59%) had quality-adjusted life years (QALYs) as the primary outcome measure, included a societal perspective in the analysis, and utilized time horizons of 10 years to lifetime. Conclusions. To continue to improve the cost-effectiveness evidence of DMTs, we recommend: lifetime horizons, societal perspectives, and QALYs; supplemental evidence with shorter horizons, payer perspectives, and clinical outcomes to inform multiple decision makers; development of modeling and input standards for comparability; head-to-head RCTs between DMTs and long-term prospective studies; and comprehensive cost-effectiveness studies that compare all appropriate DMTs.

I 1. International collaboration in freshwater ecology was examined using authorship affiliations of articles published in thirty-three spedalized journals. Most are published in Europe. 2. Researchers from four to thirty-seven different countries were represented in the 100 articles examined for each journal. Only 29% of articles were single-authored; multicountry authors' addresses (indicating international collaboration) were found for 9% (range 0-23% per journal) of articles examined. 3. Five of the eighty-nine countries listed in the addresses of the 33(K) articles together contributed >50% of total articles: United States (24.9%), Canada (8.6%), Germany (7.6%), Commonwealth of Independent States (7.0%) and Poland (5.9%). Of the fifteen countries that each produced >2,5% of total articles, the percentage representing international collaboration was highest for France (34.9%) and Canada (24.0%). The seventy-four countries that each contributed <2.5% of total articles generally had higher rates of international collaboration. 4. Researchers in the United States and Canada collaborate internationally almost twice as often in freshwater ecology than in all sdence. Much of France's extensive international collaboration is with countries that produce few articles in freshwater ecology, and their international collaboration is often exclusively with France. 5. Three journals publishing both marine and freshwater ecology articles contain more articles on the former topic, but more countries are represented in the publication of freshwater than marine research. 6. The percentage of articles that represent international collaboration is higher in freshwater ecology than in medidne, biology, chemistry and engineering, and approximates that in physics.

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PurposeThe purpose of this paper is to describe the processes the UCLA Library Website Redesign Team used to develop a new library website responsive to the needs of the broad population of UCLA Library users.Design/methodology/approachUsing a combination of structured analyses of the previous library website, user surveys, a card sort protocol and a think‐aloud protocol, the Website Redesign Team procured sufficient information to meet its redesign goals: established clear site organization and navigation, utilized user‐centered nomenclature, ensured easy access from the library homepage to relevant information, developed a unified institutional visual identity throughout the site, and enabled a content management system.FindingsStandard usability methods such as surveys and the card sort and think‐aloud protocols are essential tools for evaluating and redesigning complex multi‐layered websites. Since the redesign process is not finite, these tools contribute to keeping a website current and responsive to the needs of its users.Originality/valueThis case study provides an example that the Redesign Team hope will empower readers with tools and knowledge that they can use to perform similar tasks in their own environment.