Alzheimer's disease, Parkinson's disease and stroke are the most common CNS diseases, all characterized by progressive cellular dysfunction and death in specific areas of the nervous system. Therapeutic development for these diseases has lagged behind other disease areas due to difficulties in early diagnosis, long disease courses and drug delivery challenges, not least due to the blood-brain barrier. Over recent decades, nanotechnology has been explored as a potential tool for the diagnosis, treatment and monitoring of CNS diseases. In this review, we describe the application of nanotechnology to common CNS diseases, highlighting disease pathogenesis and the underlying mechanisms and promising functional outcomes that make nanomaterials ideal candidates for early diagnosis and therapy. Moreover, we discuss the limitations of nanotechnology, and possible solutions.
Background: Phytogenic compounds are one of many alternatives to current industry feed ingredients for the poultry industry. However, despite increased reports on the activity of phytogenic compounds against disease in poultry, there is a lack of data regarding safety and residual toxicity. This two-part study investigated the general health of broiler chickens fed Berberine, Ursolic Acid, Piceid, Honokiol and Baicalin in-feed at three different levels, and assessed the poultry tissue residue of Berberine in breast muscle, upper and lower thigh, and liver through LC/MS-MS.
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