A 6-week-old boy was referred with a generalized bullous rash since birth. Examination revealed bullous mastocytosis with initially no evidence of systemic involvement. Hepatosplenomegaly was noted at 6 months, and at 12 months he was found to have generalized lymphadenopathy. He developed bouts of vomiting associated with increased blistering. At 17 months he had sudden collapse following a brief bout of vomiting and was apneic and asystolic on arrival at the emergency department. The cause of death was attributed to massive hypotension secondary to mast cell degranulation. Although childhood mastocytosis has a favorable course in general, the subset of children with congenital bullous mastocytosis is at higher risk of sudden death and a more guarded prognosis should be given.

Museums are increasing access to their collections and providing richer user experiences via web-based interfaces. However, they are seeing high numbers of users looking at only one or two pages within 10 s and then leaving. To reduce this rate, a better understanding of the type of user who visits a museum website is required. Existing models for museum website users tend to focus on groups that are readily accessible for study or provide little detail in their definitions of the groups. This paper presents the results of a large-scale user survey for the National Museums Liverpool museum website in which data on a wide range of user characteristics were collected regarding their current visit to provide a better understanding of their motivations, tasks, engagement and domain knowledge. Results show that the frequently understudied general public and non-professional users make up the majority (approximately 77%) of the respondents. Keywords Digital cultural heritage • Museum website • User research • User groups • Survey 1 Introduction Museums have expanded their web-based offerings, providing not only access to general information about the museums, but also direct access to their holdings, digital collections and online exhibits. Various studies have explored the relationship between museums, their websites and visitors, especially how museum websites are used to connect visitors' pre-and post-visit activities to the physical museum [31]. The provision of web-based resources has opened up museums to wider and more diverse user groups and led to a significant rise in the number of visitors to museum websites B David Walsh

Bluegills (Lepomis macrochirus Rafinesque) and largemouth bass (Micropterus salmoidesLacepede) were exposed to two applications of Dursban©, an organophosphorus insecticide, at the recommended rates for mosquito control of 0.05 or 0.01 lb of active ingredient/A in experimental 0.! acre ponds. Residues of Dursban in water ! day after the applications ranged from 2.39 parts per billion (ppb) in the highest treatment to 0.97 ppb in the low treatment. Cumulative mortality in the untreated ponds during 63 days of observation was approximately 1% of the total population of each species of fish. Cumulative mortality of fishes during the same period in ponds treated at 0.0! lb/A was 3% for bluegills and 10% for bass, whereas the corresponding mortalities for the high application rate (0.05 lb/A) were 55% for bluegills and 46% for bass. Uptake of Dursban by fishes produced maximum residue values of 3.82 parts per million (ppm) in bluegills and 2.55 ppm in bass within ! to 3 days after application of the insecticide at 0.05 lb/A. These residues decreased greatly within 2 weeks to less than 0.4 ppm and were undetectable after 4 weeks. Both species of fish taken from the ponds treated at 0.05 lb/A exhibited more than 80% inhibition of brain acetylcholinesterase activity as compared to fish from untreated ponds; fishes from these ponds had not recovered normal acetylcholinesterase activity 28 days after application of the insecticide. Histological examination of tissues from bluegills and largemouth bass exposed to Dursban did not show conclusive evidence for pesticide-induced pathology. The high treatment reduced the total number of insects colonizing plate samplers by three-fourths, eliminated caddisflies, and severely reduced mayfly populations. We believe that the results of this investigation confirm the inadvisability, as suggested on product labels, of using Dursban at the current recommended rates of application for mosquito control in habitats where valuable fishery resources are to be protected. SMITH, G. 1966. Basic studies on Dursban insecticide. Down to Earth 22(2): 3-7. Dow Chemical