A direct method for C−H dicarbamoylations of phenanthrolines has been developed, which is capable of directly installing primary, secondary as well as tertiary amides. This is a significant improvement on the previous direct method, which was limited to primary amides. The metal-, light-, and catalyst-free Minisci-type reaction is cheap, operationally simple, and scalable. We demonstrate that the step efficiency toward dicarbamoylated phenanthroline targets can now be significantly improved.
A mild
and inexpensive method for direct hydrodecarboxylation of
aliphatic carboxylic acids has been developed. The reaction does not
require metals, light, or catalysts, rendering the protocol operationally
simple, easy to scale, and more sustainable. Crucially, no additional
H atom source is required in most cases, while a broad substrate scope
and functional group tolerance are observed.
A method for the C–H carboxyamidation of purines
has been
developed that is capable of directly installing primary, secondary,
and tertiary amides. Previous Minisci-type investigations on purines
were limited to alkylations and arylations. Herein, we present the
first method for the direct C–H amidation of a wide range of
purines: xanthine, guanine, and adenine structures, including guanosine-
and adenosine-type nucleosides. The Minisci-type reaction is also
metal-free, cheap, operationally simple, scalable, and applicable
to late-stage functionalizations of biologically important molecules.
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