Colonic resections were repaired in normal dogs by crushing suture, inverting suture, or staple anastomosis techniques. Dogs were sacrificed 2, 4, 7, 10, 14, 21, and 28 days following surgery. Bacterial cultures, breaking strength measurement, adhesion formation, and gross and histopathologic examinations were made. Anastomoses closed by staples showed the least tissue reaction, least neutrophilic infiltration, most mature fibrous connective tissue, most normal arrangement of muscle layers, and fewest numbers of mucoceles and necrotic areas. The staple and crushing anastomosis techniques caused significantly less reduction in luminal radius than did the inverting anastomosis technique. Bacteria were isolated least frequently and adhesions were least severe following staple anastomosis, though these results were not statistically significant. Stapled anastomosis appeared to result in a higher tensile strength of the wounds at the anastomotic sites compared with the other techniques studied. From the Departments of Veterinary Clinical Sciences (Stoloff), Veterinary Pathology (Snider, Taylor), Veterinary Physiology, Pharmacology and Toxicology (Crawford), and Veterinary Microbiology and Parasitology (Cox), School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana. The authors wish to thank Dr. M. Hugh-Jones for statistical analysis of the data.