HighlightsSpontaneous preterm birth is associated with elevated CVF RANTES and IL-1β in mid-trimester.High CVF RANTES and IL-1β correlate with FFN, pH and increased prevalence of vaginal anaerobes.Increasing/elevated CVF RANTES in mid-trimester is highly predictive of spontaneous PTB than IL-1β and FFN.

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Syntheses of trans‐isomers of ketoconazole, and the corresponding des‐acetyl, 1‐methyl‐, 1‐formyl and 1‐methanesulfonyl analogs were investigated. These isomers, along with the corresponding cis‐diastereomers were characterized by their carbon‐13 nmr spectra.

A series of 1,3‐bis(1H‐azol‐1‐yl)‐2‐aryl‐2‐propanols 17 were synthesized in an one‐pot procedure by reacting l‐aryl‐2‐(1H‐1,2,4‐triazol‐l‐yl)‐ or l‐aryl‐2‐(1H‐imidazol‐l‐yl)ethanones with dimethylsulfoxonium methide in the presence of either 1,2,4‐triazole or imidazole. The aromatic groups in 17 were either 4‐bromo‐, 4‐chloro‐, 2,4‐dichloro‐ or 2,4‐difluorophenyl. 4‐Amino‐4H‐1,2,4‐triazole was acylated with either benzoyl or 4‐toluene‐sulfonyl chloride to afford [4‐(benzoyl or 4‐toluenesulfonyl)amino]4H‐1,2,4‐triazole. Subsequent alkylations with 4‐bromo‐ or 4‐chlorophenacyl bromide produced 1‐(4‐bromo‐ or 4‐chlorophenacyl)‐4‐[(benzoyl‐ or 4‐toluenesulfonyl)amino]‐1H‐1,2,4‐triazolium bromides. Neutralizations of these salts provided the corresponding ylides.