Keywords: receptors; G protein-coupled; phospholipid methylation; methionine; folic acid; membrane fluidity; purines; de novo synthesis Schizophrenia is a complex psychiatric disorder affecting approximately 1% of the population worldwide with a typical onset between the late teens and midthirties, often in the absence of significant prodromal psychiatric symptoms.1 Decades of research have yielded many theories on the origin of schizophrenia, although none provides a satisfying mechanistic explanation. Logically, dysfunctional neurotransmission is the most widely held theory, and specific abnormalities involving dopaminergic, 2 glutamatergic, 3 GABAergic 4 and nicotinic cholinergic 5 signaling have been proposed. Of these, the 'Dopamine Hypothesis' is dominant, based largely on the recognized therapeutic efficacy of drugs which block D2-like dopamine receptors (ie D2, D3 and D4 receptors), although their specific mechanism of benefit and the importance of individual receptor subtypes remains unclear. The D4

Therapeutic study, level III.

This report describes a technique for correct positioning of a stent in an ostial stenosis by using a second wire passed through the last cell of a stent. The anchor wire technique, first described by Szabo et al. [Szabo S, Abramowitz B, Vaitkus PT. Am J Cardiol 2005;96:212H], will facilitate precise ostial stent placement and eliminate errors of positioning inside or outside the ostial narrowing.