STUDIES ON GLUCOSE PHOSPHORYLATION IN RAT LIVER 455 activities found earlier (Greenberg and Glick, 1960 a), after administration of ACTH, are consistent with the requirement of the hypothesis of Haynes and Berthet (1957) that TPNH generation be increased via the G-6-P dehydrogenase reaction, and that the source of G-6-P be G-l-P derived from glycogen. An increase in phosphorylase activity leading to production of G-l-P would also be expected, and this has been borne out by subsequent studies to be reported later.

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