Milan Kundera's novel Immortality bears a close relation to contemporary social science debates about the production of the self. Commentators like Kleinman and Mishler seem to have introduced a new version of authenticity based on a reinvention of the Romantic subject with the interview (as the medium) and the narrative (as the content) portrayed as the means for constructing and sharing biographical expenence. Unlike such contem porary Romantics, Kundera examines how the subject is constructed in literary biography and mass media "imagology." The authors show how Kundera's work leads in two possible directions: an analysis of the interview society and a concern with strategies for the invention of the self. By locating styles of the self, the authors reveal lively and skillful biographical work, overlooked by cultural critique and not reducible to any structural determinism.

The possibility that bacteria may have evolved strategies to overcome host cell apoptosis was explored by using Rickettsia rickettsii, an obligate intracellular Gram-negative bacteria that is the etiologic agent of Rocky Mountain spotted fever. The vascular endothelial cell, the primary target cell during in vivo infection, exhibits no evidence of apoptosis during natural infection and is maintained for a sufficient time to allow replication and cell-to-cell spread prior to eventual death due to necrotic damage. Prior work in our laboratory demonstrated that R. rickettsii infection activates the transcription factor NF-B and alters expression of several genes under its control. However, when R. rickettsiiinduced activation of NF-B was inhibited, apoptosis of infected but not uninfected endothelial cells rapidly ensued. In addition, human embryonic fibroblasts stably transfected with a superrepressor mutant inhibitory subunit IB that rendered NF-B inactivatable also underwent apoptosis when infected, whereas infected wild-type human embryonic fibroblasts survived. R. rickettsii, therefore, appeared to inhibit host cell apoptosis via a mechanism dependent on NF-B activation. Apoptotic nuclear changes correlated with presence of intracellular organisms and thus this previously unrecognized proapoptotic signal, masked by concomitant NF-B activation, likely required intracellular infection. Our studies demonstrate that a bacterial organism can exert an antiapoptotic effect, thus modulating the host cell's apoptotic response to its own advantage by potentially allowing the host cell to remain as a site of infection.

Renowned scholar of qualitative research methods David Silverman delivers an indictment of contemporary qualitative research methods. The book is meant to be an introduction (or "pre-textbook") to the subject of qualitative research and definitely not a "how-to" manual. In evaluating contemporary qualitative research methods, Silverman's book primarily focuses on ethnography and conversation analysis. Intentionally personal and biased, Silverman's plainly-stated goal for this book is to "debunk the accepted understandings" of qualitative research and elicit an interest in the arguments within the field of qualitative inquiry , and he succeeds on both accounts .

Atkinson and Silverman’s (1997) depiction of the Interview Society analysed the dominance of interview studies that seek to elicit respondents ‘experiences’ and ‘perceptions’. Their article showed that this vocabulary is deeply problematic, assuming an over-rationalistic account of behaviour and a direct link between the language of people’s accounts and their past and present psychic states. In this article, using a Constructionist approach, I develop these ideas, by asking what sort of data are we trying to retrieve through interviews, i.e. what do interviews reveal? I go on to examine and discount the claimed intellectual auspices for most interview studies and the way in which interview data are usually analysed. I conclude by showing how the reliability of interview transcripts can be improved and the analysis of interview data made more robust.

Although the AIDS pandemic has generated considerable social science research, the focus has almost entirely been on epidemiology and on survey research studies of health knowledge and behaviour. In contrast, this paper offers an early report on ongoing work into HIV and AIDS counselling as it occurs in practice in a number of English clinics. An analysis of transcripts of such naturally occurring encounters reveals how professionals and clients organise their talk in relation to the 'delicate' issues to be discussed. Particular attention is paid to the phenomenon of delay in the production of 'delicate' items and to the social organisation of the description of such items. Drawing, in part, on methods from conversation analysis, it is shown how a detailed analysis of how talk is produced in naturally occurring settings can generate findings relevant to professional practice.

To investigate whether the hantaviruses replicate in endothelial cells, we inoculated human umbilical vein endothelial cells with several pathogenic and nonpathogenic strains of hantavirus. Intracytoplasmic, virus-specific granular fluorescence was detected initially at three days postinoculation and nearly 100% of cells contained viral antigen at 10 days. Cytopathic effect or inclusion bodies were not observed. The in vitro demonstration of the susceptibility of endothelial cells to hantaviruses corroborates in vivo findings, and suggests that endothelial cells may serve as target cells in hemorrhagic fever with renal syndrome.

With information systems (IS), as in other social sciences, the critique of quantitative research can lead to an oversimplified opposition between ‘positivism’ and ‘interpretivism’. This is one reason why qualitative IS research sometimes unnecessarily limits itself to the study of participants' meanings. A simple tabulation of published qualitative research is used to reveal the predominance of interview‐based studies in both sociology and IS. This is followed by a brief account of the limits of both quantitative studies of ‘objective’ variables and qualitative studies of ‘subjective meanings’. The emerging case for IS research on organizational practices is set out, coupled with an account of Suchman's (1987) study of how workers make use of a computer‐based system attached to a photocopier. The paper concludes with a call for an end to paradigm wars in organizational studies.

Counseling is a pervasive activity in contemporary institutional life. This article focuses on the ways in which troubles—as socially constructed realities—are talked into being in two counseling settings: a British hemophilia center that counsels individuals who have become HIV‐positive through the transfusion of infected blood products and a family therapy center in the United States. Drawing upon conversation analytic studies of “troubles talk,” three major topical and interactional continuities in the two settings are revealed. They involve trouble definitions, trouble remedies, and accessing the social contexts of clients' troubles. Using ideas from Foucault, the article analyzes counseling as a professional technology for inciting troubles talk. As such, counseling functions as one of a variety of institutional discourses within which troubles talk may be elicited and organized, power moves, and people may be constructed as objects of power. The article thus serves as an initial attempt to synthesize strands of Foucauldian and conversation analytic work at an empirical, rather than purely theoretical, level.