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We have presented a retrospective study of 129 patients with platelet counts of 1,OOO X 109/L or more-72 with myeloproliferative disorders (MPD), and 57 with reactive thrombocytosis (RT)-in an effort to determine the incidence of thrombohemorrhagic complications. Thrombotic disorders occurred with approximately equal frequency in the two groups, being found in three patients (4%) with MPD and three (5%) with RT when the platelet count was over 1,OOO X 109/L and in 11% of the patients in each group when the platelet count was less than 1,OOO X 109/L. In contrast, bleeding manifestations were more common in MPD, where 36% of patients were affected on one or more occasions versus only 4% of those with RT. However, bleeding was generally not severe, with only six patients requiring transfusions, and three of these patients had been receiving aspirin or corticosteroids when they developed severe gastrointestinal bleeding.

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Levels of I were determined in selected foods and dietary supplements, and in samples of the British 'Total Diet'. The average concentration of I in British milk collected in thirteen areas on four occasions during 1990 and 1991 was 150 pg/kg (range 40-310 pglkg), compared with 230 pg/kg in 1977-79. No difference was found between skimmed and whole milk. Winter milk contained 210 pg/kg while summer milk contained 90 pg/kg. Regional differences were less pronounced than seasonal differences. Levels in fish and fish products were between 110 and 3280 pg/kg. Edible seaweed contained

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The primary diagnosis of non-Hodgkin lymphoma/leukemia by fine-needle aspiration (FNA) is still controversial and relatively underused. We evaluated our FNA experience with lymphomas using the revised European-American classification of lymphoid neoplasms to determine the reliability of FNA when combined with flow cytometry in the diagnosis of lymphoma, the types of diagnoses made, and the limitations of this technique. Slides and reports from all lymph node and extranodal FNAs performed during the period January 1, 1993, to December 31, 1998, with a diagnosis of lymphoma or benign lymphoid process were reviewed. There were 290 aspirates from 275 patients. These included 158 cases of lymphoma, of which 86 (54.4%) were primary and 72 (45.6%) were recurrent. There were 44 aspirates suggestive of lymphoma and 81 benign/reactive diagnoses. With diagnoses suggestive of lymphoma considered as positive for lymphoma, levels of diagnostic sensitivity and specificity were 95% and 85%, respectively. Specificity was 100% when only definitive diagnoses of lymphoma were considered. Clearly, FNA and immunophenotyping by flow cytometry are complementary and obviate a more invasive open biopsy for many patients with lymphadenopathy.