Change and correlates of change in high and low density lipoprotein cholesterol (HDL and LDL) were studied in a prospective population-based study of 614 men and women in Rancho Bernardo, CA, 1972-1980. Correlations between baseline and follow-up examination an average of six years later were 0.72 for HDL and 0.68 for LDL, and 86% of HDL and 89% of LDL values were within +/- 30% of their original values. Predictions of HDL and LDL change were determined by multivariate analysis. Regression to the mean was the strongest single predictor of lipoprotein change and was more important than behavioral change. Among the behavioral variables, HDL change was positively associated with change in alcohol use in both sexes and with change in postmenopausal estrogen use in women and was inversely associated with change in obesity index in men. LDL change correlated positively with change in obesity index in both sexes. Change in reported cigarette use or exercise was unrelated to changes in HDL and LDL in this analysis. The similarity of lipoprotein values at baseline and follow-up suggests reasonable reliability and prognostic validity for a single HDL or LDL measurement. The multivariate analysis results generally confirm current cross-sectionally derived concepts about behavioral correlates of lipoproteins. However, the degree of regression to the mean indicates the wisdom of repeat measurements, particularly for persons with extreme values.
Purpose: To describe the anesthetic management of newborn omphalopagus conjoined twins undergoing a series of diagnostic and surgical procedures which culminated in successful separation at one month of age.Clinical features: Evaluations of the extent of shared organ systems were carried out without the need for anesthesia. The twins were anesthetized twice, once for insertion of skin expanders, and later for surgical separation. Various airway management techniques were utilized. To facilitate surgical separation, caudal epidural catheters were inserted in an effort to provide both operative and post-operative analgesia. In addition, prior to the induction danesthesia, the extent of cross-circulation between twins was assessed, Conclusion: Caudal epidural catheters can be used to provide both operative and post-operative analgesia. Early extubation, another benefit of regional analgesia, was not achieved because both twins developed respiratory failure in the immediate postoperative period. Testing for the extent of cross-circulation between twins proved valuable, allowing for detailed scripting of the complex induction sequence and airway management. A LTHOUGH conjoined twins are a rare occurrence, several successful operative separations have been reported.l,3,4, (>9 To our knowledge, none of these reported operations have included regional anesthesia as part of the intraoperative anesthetic management or for postoperative analgesia. In addition, there are no reports of testing the extent of cross-circulation between conjoined twins to evaluate what might occur during the induction of anesthesia. We report the successful separation of omphalopagus conjoined twins using caudal epidural anesthesia with continuous infusion of local anesthetic for postoperative analgesia. We also tested for the extent of cross circulation between twins with both inhaled and iv drugs, and suggest how that information can be used to plan the induction of anesthesia and management of the airway.
ObjectifCase report Male omphalopagus twins were delivered by Cesarean section at 36 weeks gestation. They needed no resuscitation at birth. The combined birth weight was 5600 g and they shared a single umbilical cord. TheyFrom the
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