The increasing access to brain signal data using electroencephalography creates new opportunities to study electrophysiological brain activity and perform ambulatory diagnoses of neurological disorders. This work proposes a pairwise distance learning approach for Schizophrenia classification relying on the spectral properties of the signal. Given the limited number of observations (i.e. the case and/or control individuals) in clinical trials, we propose a Siamese neural network architecture to learn a discriminative feature space from pairwise combinations of observations per channel. In this way, the multivariate order of the signal is used as a form of data augmentation, further supporting the network generalization ability. Convolutional layers with parameters learned under a cosine contrastive loss are proposed to adequately explore spectral images derived from the brain signal. With the proposed method achieving a best of 0.95 ± 0.05, 0.98 ± 0.02 and 0.92 ± 0.07 in terms of Accuracy, Sensitivity and Specificity respectively. Results on a case-control population show that the features extracted using the proposed neural network are superior than baselines to diagnose Schizophrenia, suggesting the existence of non-trivial electrophysiological brain patterns able to capture discriminative neuroplasticity profiles among individuals.

No abstract

Functional Magnetic Resonance Imaging (fMRI) is a neuroimaging technique with pivotal importance due to its scientific and clinical applications. As with any widely used imaging modality, there is a need to ensure the quality of the same, with missing values being highly frequent due to the presence of artifacts or sub-optimal imaging resolutions. Our work focus on missing values imputation on multivariate signal data. To do so, a new imputation method is proposed consisting on two major steps: spatial-dependent signal imputation and time-dependent regularization of the imputed signal. A novel layer, to be used in deep learning architectures, is proposed in this work, bringing back the concept of chained equations for multiple imputation [1]. Finally, a recurrent layer is applied to tune the signal, such that it captures its true patterns. Both operations yield an improved robustness against state-of-the-art alternatives. The code is made available on Github.Preprint. Under review.

The increasing access to brain signal data using electroencephalography creates new opportunities to study electrophysiological brain activity and perform ambulatory diagnoses of neuronal diseases. This work proposes a pairwise distance learning approach for Schizophrenia classification relying on the spectral properties of the signal. Given the limited number of observations (i.e. the case and/or control individuals) in clinical trials, we propose a Siamese neural network architecture to learn a discriminative feature space from pairwise combinations of observations per channel. In this way, the multivariate order of the signal is used as a form of data augmentation, further supporting the network generalization ability. Convolutional layers with parameters learned under a cosine contrastive loss are proposed to adequately explore spectral images derived from the brain signal. Results on a case-control population show that the features extracted using the proposed neural network lead to an improved Schizophrenia diagnosis (+10pp in accuracy and sensitivity) against spectral features, thus suggesting the existence of non-trivial, discriminative electrophysiological brain patterns.Preprint. Under review.