Antipodal relationship: A convergent synthetic pathway leading to 4‐hydroxy‐2‐pyridinones was involved in the synthesis of apiosporamide (1) and YM‐215343 (2). Both have an antipodal relationship to the natural metabolites, whose relative and absolute configurations have been established. Activated β‐alanine enolate equivalents derived from β‐lactams were the key to the synthesis.

A collaborative environmental service-learning project was implemented between upper-level undergraduate science majors and graduate chemistry students at a large state school and first-year students at a small private liberal arts college. Students analyzed the water quality in a nature preserve by determining the quantities of 12 trace metals, seven anions including nitrate and phosphate, and Escherichia coli and coliform bacteria. Dissolved oxygen, temperature, and pH were recorded in the field as well. Students publicly communicated their results by creating deliverables such as a standard operating procedures manual, a PowerPoint presentation, and a professional-quality poster. The project was successful and student learning and interest in environmental chemistry were enhanced. The community response was particularly positive.

No abstract

No abstract

No abstract