Background: Subcellular distribution of NADPH oxidase in macrophages is unclear. Results: In mature (activated) macrophages, NADPH oxidase is contained in a storage compartment and is internalized by clathrin-coated pits. Conclusion: NADPH oxidase trafficking is regulated by external factors. Significance: Subcellular localization of NADPH oxidase relates to pathogen eradication, nature, and severity of oxidative tissue stress as well as redox signaling.
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