We found that patients who underwent the MP-TKA scored better on the FJS than those who underwent the PS-TKA; particularly with regard to deep knee flexion and stability of the prosthesis. The MP-TKA design may offer improved patient outcomes because of its highly congruent medial tibiofemoral articulation.

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accelerated expression of Runx2 was inhibited by the pretreatment with Sirt1 inhibitor in osteoarthritic chondrocytes. Also, the IL-1binduced production of MMP-13 from chondrocytes was reduced by the pretreatment with Sirt1 inhibitor. Conclusions: Our study revealed that Sirt-1 inactivation trended to inhibit the Runx2 expression and IL-1beta-induced production of MMP-13 in chondrocytes. The Runx2 has been reported to have an important role as a promotor of activation of MMP-13 in chondrocytes (4). Thus, our findings suggest that the NAD-dependent deacetylase Sirt-1 may upregulate the osteophyte formation and the expression of cartilage degrading enzyme MMP-13 through the mechanism involving the acceleration of the osteogenic transcription factor Runx2 in OA cartilage tissues. Since it is well known that Sirt-1 activity is affected by several stresses as well as aging, Sirt-1 may be involved in the pathology of OA. Our study may provide a pathologic mechanism linking the NADdependent deacetylase Sirt-1 and its modulation of Runx2 in OA.