Objective To determine what impact reliance on self reported smoking status during pregnancy has on both the accuracy of smoking prevalence figures and access to smoking cessation services for pregnant women in Scotland. Design Retrospective, cross sectional study of cotinine measurements in stored blood samples. Participants Random sample (n=3475) of the 21029 pregnant women in the West of Scotland who opted for second trimester prenatal screening over a one year period. Main outcome measure Smoking status validated with cotinine measurement by maternal area deprivation category (Scottish Index of Multiple Deprivation). Results Reliance on self reported smoking status underestimated true smoking by 25% (1046/3475 (30%) from cotinine measurement v 839/3475 (24%) from self reporting, z score 8.27, P<0.001). Projected figures suggest that in Scotland more than 2400 pregnant smokers go undetected each year. A greater proportion of smokers in the least deprived areas (deprivation categories 1+2) did not report their smoking (39%) compared with women in the most deprived areas (22% in deprivation categories 4+5), but, because smoking was far more common in the most deprived areas (706 (40%) in deprived areas compared with 142 (14%) in affluent areas), projected figures for Scotland suggest that twice as many women in the most deprived areas are undetected (n=1196) than in the least deprived areas (n=642). Conclusion Reliance on self reporting to identify pregnant smokers significantly underestimates the number of pregnant smokers in Scotland and results in a failure to detect over 2400 smokers each year who are therefore not offered smoking cessation services.

The purpose of this investigation was to examine power performance in jump squats when using the complex and contrast training methods. Eleven (n = 11) women participated in a familiarization session and in three randomly ordered testing sessions. One session involved completing sets of power exercises (jump squats) before sets of half squats (traditional method). The second session involved sets of half squats before sets of jump squats (complex method). A third session involved the alternation of sets of half squats and jump squats (contrast method). No significant difference in jump squat performance between each of the training methods was found. There was a significant difference (p < 0.05) in the first set of each session, with the complex method having a significantly lower peak power. Further, there was a significant difference (p < 0.05) in performance changes between the higher and lower strength groups, with the higher strength group having a greater improvement in performance using the contrast training method compared with the traditional method. It was concluded that contrast training is advantageous for increasing power output but only for athletes with relatively high strength levels.

Higher early pregnancy levels of sFlt-1 and PlGF were associated with a decreased risk of adverse perinatal outcome.

The risk of adverse perinatal outcome among 8839 women recruited to a multicenter, prospective cohort study was related to maternal circulating concentrations of trophoblast-derived proteins at 8-14 wk gestation. Women with a pregnancy-associated plasma protein A (PAPP-A) in the lowest fifth percentile at 8-14 wk gestation had an increased risk of intrauterine growth restriction [adjusted odds ratio, 2.9; 95% confidence interval (CI), 2.0-4.1], extremely premature delivery (adjusted odds ratio, 2.9; 95% CI, 1.6-5.5), moderately premature delivery (adjusted odds ratio, 2.4; 95% CI, 1.7-3.5), preeclampsia (adjusted odds ratio, 2.3; 95% CI, 1.6-3.3), and stillbirth (adjusted odds ratio, 3.6; 95% CI, 1.2-11.0). The strengths of the associations were similar when the test was performed before 13 wk gestation or between 13 and 14 wk gestation. In contrast, levels of free beta-human CG, another circulating protein synthesized by the syncytiotrophoblast, were not predictive of later outcome in multivariate analysis. PAPP-A has been identified as a protease specific for IGF binding proteins. We conclude that control of the IGF system in the first and early second trimester trophoblast may have a key role in determining subsequent pregnancy outcome.

In the second trimester of pregnancy, measuring inhibin A in maternal serum, in combination with measurements of alpha-fetoprotein and beta subunit of human chorionic gonadotropin, significantly improved the rate of detection of Down's syndrome.

II-2.

No abstract

No abstract