The objective of green analytical chemistry is to protect the natural environment by developing eco-friendly analytical methods by strictly adhering to the quality practices in pharmaceutical analysis. Reverse phase high performance liquid chromatography is the most extensively utilized technique in the pharmaceutical industry today being employed in nearly every stage of the discovery, development and manufacturing of new drug products [1]. European medicine agency mentioned that solvents like Acetonitrile is ranked as hazardous solvents [2] and because of their inherent toxicity, safe detoxification of the waste solvents is essential, which may lead to high to very high disposal costs [3]. Green liquid chromatography includes reduction in the usage of toxic solvents and changing to eco-friendly solvents [4]. Owing to the toxic properties of acetonitrile, aqueous waste streams containing acetonitrile are typically disposed as chemical waste [5]. Esomeprazole (ES) chemically (magnesium bis[5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]
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