Breast cancer is the most frequent cancer in females in the world and is the second most common cancer in India after cervical cancer. The breast cancer is second most common reason of loss of existence in each developed and additionally most of the growing countries. For the appraisal of prognosis of breast cancer commonly followed is the NOTTINGHAM PROGNOSTIC INDEX (NPI) which includes- tumor size, histological tumor grade, lymph node metastasis and hormone receptor status. These prognostic component help in administration and therapeutic requirement of breast cancer patient.1. To study the MRM specimens for size, grade of the tumor, LVI and LN metastases and the ER/PR receptors of the tumor. 2.To study the association of ER/PR status with the above mentioned prognostic parameters.This three-year study includes 50 histopathologically confirmed cases of carcinoma breast. The tumor type, grade, LNM, LVE were reported on H & E. The ER-PR study was done of all 50 cases. The tumor size, grade, NM, LVE were correlated with receptor status. Out of 50 cases majority (7.5%) of cases were in 41-50 years of age group, and tumor size was between 2-4 cm in (17.5%) cases; majority were of grade II carcinoma (17.5%) of which 13% were ER-PR positive. Out of 35 cases with negative LNM and LVE, 26 cases (13%) were ER-PR positive.In our observation there is no association between higher histological grade and ER-PR status. No obvious correlation with tumor size was noted. But increase in tumor size could also be a poor predictor of ER-PR status. LNM, LVE is poor predictor of ER-PR status.
Breast cancer is the most common cancer in women worldwide, comprising 16% of all -female cancers. It is by far the most frequent cancer in female, both in developed and developing regions and is second overall next only lung. In India, breast cancer is the most common cancer among women in many regions and has overtaken cervix cancer, which was the most frequent cancer a decade ago 5 As in other developing regions, the mortality rates for breast cancer in India are high in comparison to its incidence rates. A poor survival may be largely explained by the lack of or limited access to the early detection services and treatment. Though clinical examination of the breast lump and the age of the patient can provide information about the nature of the lump, Histopathological examination is necessary to establish the diagnosis. To classify the breast lesions and study them with age, clinical presentation and various pathological parameters. The present study of the breast lesions was performed in the department of pathology in a general teaching hospital and tertiary referral health care centre in Mumbai. All the assimilated data was collected and analysed to find the incidence and frequency of lesions. Infiltrating duct carcinoma (IDC) is the most common breast malignancy. Grade -2 IDC’s were more common than grade- 1 and grade-3 IDC’s. Breast cancers were bulky and presented at an advanced stage in younger population. Breast carcinomas in our population presents as locally advanced cancer, with predominance of higher histological grade and higher stage in view of lack of or limited access to the early detection services and treatment.
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