• 2H 2 O was determined. Magnetic moment and reflectance spectral studies revealed that an octahedral geometry could be assigned to all the prepared heterochelates. Ligands (H 2 A n ) and their heterochelates were screened for their in-vitro antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Serratia marcescens bacterial strains. The kinetic parameters such as order of reaction (n), the energy of activation (E a ), the pre-exponential factor (A), the activation entropy ( S # ), the activation enthalpy ( H # ) and the free energy of activation ( G # ) are reported.

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In this work novel pyrazolone based semicarbazone derivatives and their spectroscopic and biological activities were investigated. Pyrazolone based semicarbazone ligands and their Fe(III) and Mn(III) heterochelates were synthesized. The structure of semicarbazone ligands were confirmed by 1H NMR, IR, elemental analysis and their heterochelates were confirmed by thermal studies (TGA/DTG & DSC) and FAB mass spectroscopy. All the ligands and heterochelates were screened for antimicrobial study against Gram positive (Bacillus megaterium, Bacillus subtilis) and Gram negative (E. coli, Klebsiella) microorganisms. The results confirmed that semicarbazone based heterochelates have a great potential and significant for further investigation.