A case of self-healing reticulohistiocytosis is reported. Our case differed from those previously reported in that tumors developed 17 days after birth (instead of at birth) and all tumors disappeared rapidly within three weeks (instead of two to three and one-half months). Hematologic abnormalities such as absolute neutropenia, marked lymphocytosis with many atypical cells, and atypical monocytes in bone marrow in association with this disease have not previously been reported. The patient had palpable liver which persisted with absolute neutropenia for about a month. The diagnosis of self-healing reticulohistiocytosis was confirmed by characteristic histology and by the demonstration of Langerhans' cells with typical granules in the tumor cells.

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