No abstract

Cystic dystrophy of the duodenal wall is a rare form of the disease which was described in 1970 by French authors who reported the presence of focal pancreatic disease localized in an area comprising the C-loop of the duodenum and the head of the pancreas. German authors have defined this area as a "groove". We report our recent experience on cystic dystrophy of the paraduodenal space and systematically review the data in the literature regarding the alterations of this space. A MEDLINE search of papers published between 1966 and 2010 was carried out and 59 papers were considered for the present study; there were 19 cohort studies and 40 case reports. The majority of patients having groove pancreatitis were middle aged. Mean age was significantly higher in patients having groove carcinoma. The diagnosis of cystic dystrophy of the duodenal wall can now be assessed by multidetector computer tomography, magnetic resonance imaging and endoscopic ultrasonography. These latter two techniques may also add more information on the involvement of the remaining pancreatic gland not involved by the duodenal malformation and they may help in differentiating "groove pancreatitis" from "groove adenocarcinoma". In conclusion, chronic pancreatitis involving the entire pancreatic gland was present in half of the patients with cystic dystrophy of the duodenal wall and, in the majority of them, the pancreatitis had calcifications.

The advent of new drugs can rapidly increase the number of substances causing acute pancreatitis. This is the case of tyrosine kinase inhibitors; these drugs are currently used for chronic myeloid leukemia, gastrointestinal stromal tumors, unresectable hepatocellular carcinomas and advanced renal cell carcinomas that and they have been reported to cause acute pancreatitis or asymptomatic elevations of serum pancreatic enzymes. Of the classes of drugs capable of inducing acute pancreatitis, we aimed to evaluate, in which class tyrosine kinase inhibitors can be allocated. A search was carried out using the MEDLINE database in order to select the data existing in the literature on pyrimidines and acute pancreatitis or serum lipase/amylase elevation covering the period from January 1966 to January 2010; thirteen papers were found and utilized for this review. Based on the data in the literature, we found that tyrosine kinase inhibitors may often cause an increase in pancreatic enzymes in plasma and patients treated with these drugs, especially those who are treated with sorafenib, might be at risk of developing acute pancreatitis. Whether acute pancreatitis due to tyrosine kinase inhibitors is associated only with sorafenib or may also be caused by other drugs of the same class remains an open question. Recent patents on tyrosine kinase inhibitors and acute pancreatitis are pointed out in this review.

Seven waste thermoplastic polymers (polypropylene, polyethylene film, polyethylene terephthalate, polystyrene, acrylonitrile-butadiene-styrene, high-impact polystyrene and polybutadiene terephthalate, denoted as PP, PE (film), PET, PS, ABS, HIPS and PBT, respectively) and four synthetic mixtures thereof with different compositions representing commingled postconsumer plastic waste and waste of electrical and electronic equipment were studied by means of simultaneous thermogravimetry/differential scanning calorimetry coupled with Fourier transform infrared spectroscopy (TG/DSC-FTIR) under pyrolytic conditions (inert atmosphere). By summing all the heat change contributions due to physical and/or chemical processes occurring (i.e., melting, decomposition), an overall energy, defined as the degradation heat, was determined for both single component and their mixtures. It was found to be about 4-5 % of the exploitable energy of the input material. Vapors evolved during the pyrolysis of single-component polymers and their mixtures, analyzed using the FTIR apparatus, allowed identifying the main reaction products as monomers or fragments of the polymeric chain. Results from TG/DSC runs and FTIR analysis show that there is no interaction among the plastic components of the mixtures during the occurrence of pyrolysis.

CFR-PEEK plates proved as reliable as metallic plates in the treatment of proximal humeral fractures. The advantages of these new devices include a better visualization of fracture reduction during intraoperative fluoroscopic assessment and easy hardware removal due to the absence of screw-plate cold fusion.