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Well-preserved SSE-dipping low-angle normal faults (LANF) active during the Early Permian (Cisuralian) were recognized along the northern margin of the Orobic Basin (central Southern Alps, N Italy). These faults, which escaped most of the Alpine deformations, exhumed the Variscan basement during the deposition of the upper part of the Lower Permian succession (Pizzo del Diavolo Formation). Fault planes show evidence of frictional processes typical of the upper crust associated with hydrothermal circulation, responsible for the deposition of cm to m thick tourmalinite and Uranium mineralization.The recognized LANFs interacted with high-angle normal faults producing half grabens that stored the Lower Permian deposits, where synsedimentary fault activity in their hangingwall is testified by abrupt vertical and lateral facies changes, thickness variations and by soft-sediment deformations.Mesoscopic structures, exposed in the hangingwall of a major LANF (the Aga-Vedello Fault system) along a synthetic high-angle normal fault, include conjugate normal faults, horst-and-graben, domino-