Background. In order to expand the hydro-mineral base of Truskavets’ spa by diluting brine (130 g/L), two new sulphate-chloride sodium-magnesium mineral waters "Myroslava" (5 g/L) and "Khrystyna" (10 g/L) were created. This report is the first in a series of experimental studies of their physiological activity in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 220-300 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the control group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The day after the completion of the drinking course in all rats assessed the state of autonomous regulation by parameters of the HRV. The plasma levels of the hormones of adaptation were determined: corticosterone, triiodothyronine and testosterone (by the ELISA); as well as electrolytes, nitric metabolites, lipid peroxidation products and antioxidant enzymes as well as cholesterol, glucose, amylase and middle mass molecules. Most of the listed parameters of metabolism as well as 17-ketosteroids were determined in daily urine. In the adrenal glands the thickness of glomerular, fascicular, reticular and medullar zones was measured. Results. To identify exactly those parameters, the set of which three groups of animals differ significantly from each other, the information field of the registered parameters was subjected to discriminant analysis. The program included in the model 6 endocrine and 11 metabolic parameters, as well as glomerular filtration. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have similar neuroendocrine and metabolic effects on healthy old female rats significantly different from daily water.
The management of a rural tourism cluster based on an economic-mathematical model stipulates the use of mathematical modeling methods to optimize the economic parameters of the cluster's activity. Therefore, the practical aspects of the application of a system approach to the development and improvement of the management system in a rural tourism cluster are substantiated. The article aims to develop an economic-mathematical model for the optimization of the management of the rural tourism cluster parameters. The model uses the Kalman filter and deterministic feedback to evaluate the state of the dynamic system based on observations. The developed models and the management optimization algorithm are synthesized in the automatized information-analytical management subsystem. The typical list of business processes in the activity of a rural tourism cluster is characterized to specify managerial actions and improve their efficiency and performance. The ways of the algorithm's integration into the automatized information-analytical management subsystem are outlined. Overall, the article offers the method of optimization of rural tourism cluster management based on mathematical modeling and management optimization.
Background. Earlier in an experiment on rats, we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa has a significant modulating effect on the parameters of metabolism and the autonomic nervous, endocrine and immune systems. In this study, we combined data obtained on the same animals, in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 230-290 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the second (control) group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The object of the study were the metabolic, neuro-endocrine and immune parameters. Results. The method of discriminant analysis revealed 31 parameters, according to which all four groups of animals differ from each other. Classification accuracy is 100%. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa has both similar and specific effects on the neuroendocrine-immune complex and metabolism at healthy old female rats with weekly use. This provides a basis for preclinical studies.
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