An enantioselective nickel(0)-catalyzedC À Hf unctionalization of indoles and pyrroles that does not require the typical Lewis basic directing groups is disclosed. The reaction provides access to valuable tetrahydropyridoindoles and tetrahydroindolizines in high yields and enantioselectivity under mild reaction conditions.T he process is characterized by aclear endo-cyclization preference to yield the sought-after six-membered-ring products.K ey for the success of the activation and selectivity in the cyclization was the development of anovel chiral SIPr carbene ligand analogue with very bulky flanking groups.
Enantioselective Pd(0)-catalyzed C-H functionalizations of ketene aminal phosphates provide isoindoline scaffolds with high enantioselectivity at ambient temperature. The high level of enantiocontrol is enabled by a tailored monodentate electronrich phosphine ligand featuring a point-chiral phospholane module and a bulky atropchiral binaphthyl backbone.
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