1716frequency mode corresponds to the CCC bend (476 cm-I). The out-of-plane bending modes of the CH2 group in the allyl radical have lower frequencies (786 and 761 cm-I) than the same mode in propene (959 cm-') but higher frequency than the pyramidal motion of the radical center in the ethyl radical. These out-ofplane bending motions are predicted to be responsible for a very J. Am. Chem. SOC. 1983SOC. , 105, 1716SOC. -1722 with lower or similar frequency. The present study should be valuable for the identification of the spectra of the allyl radical and of the cyclopropyl radical. Acknowledgment. We gratefully acknowledge many stimulating discussions with Dr. J. Pacansky (IBM Research Laboratory).intense bandnear 770 cm-icharacteristic of ;he IR spectrum df the allyl radical. Previously, we had reported that the lowest frequency mode in the cyclopropyl radical was the a C H bending model (713 cm-I). The allyl radical has several vibrational modes Registry No. CH2CHCH2 radical, Abstract: A model of intramolecular electrostatic effects (called the induced dipole moment and energy (IDME) method) was derived by extending the method originally proposed by Del Re for calculating dipole moments and charge distributions. The IDME procedure consists of taking bond dipoles, calculated by the Del Re procedure, and allowing for nonadjacent dipole interactions by taking all components of bond polarizabilities into account. The method is applied to some simple halides, ketones, and ethers. The total dipole moments are well calculated and charge distributions reproduce many known trends. The calculated energies agree better with experiment overall than those calculated earlier by the modified Smith-Eyring method.between charges (dipoles) in different bonds is large, or at least large compared to the diameters of the atoms or to the effective distance between charges in the same bond. With a few significant exceptions, the two methods (charges or dipoles) give results that are substantially the same. Neither was able to explain, for instance, the high experimental value of the dipole moment of 2P,3a-dichloro-5-cholestane15 and of a number of other 1,2-diaxial dihalides.A method for treating the problem of induction, dealing with charges on the classical level, was long ago developed by Smith (1) The work was supported in part by the Republic Research Fund, SR Serbia. Abstracted from the Ph.D. thesis of L.D.-M. submitted to the
Previous studies demonstrated insulin resistance and increased prevalence of impaired glucose tolerance and type 2 diabetes mellitus in patients with primary hyperparathyroidism (PHPT). The effect of curative parathyroidectomy on insulin sensitivity was associated with conflicting results depending on which method for measuring the insulin sensitivity has been used. There was no improvement using HOMA and QUICKI while minimal model demonstrated significant improvement in insulin sensitivity. The aim of our study was to evaluate the insulin sensitivity before and after parathyroidectomy in patients with PHPT using a euglycemic clamp. 44 patients with PHPT and 11 age and body mass index matched healthy controls participated in study protocol. Before surgery M values and HOMA IR suggest insulin resistance in patients with PHPT. There was no difference in M index (3.74±1.89 vs. 4.62±2.27, p>0.05), HOMA IR (2.94±1.39 vs. 3.29±0.81, p>0.05), AUC glucose (863.0±261.3 vs. 842.3±165.5, p>0.05), AUC insulin (7068.7±4159.0 vs. 7229.6±2581.7, p>0.05), ISI (4.73±2.77 vs. 4.25±2.94, p>0.05) and AIR (47.89±32.05 vs. 38.96±21.20, p>0.05) between patients with PHPT and HC. There was significant improvement in insulin sensitivity after parathyroidectomy but both preoperative and postoperative M values were not significantly different in comparison to HC. There were no significant changes in HOMA IR, AUC glucose, AUC insulin, ISI and AIR before and after therapy. In conclusion, we observed significant improvement in insulin sensitivity after parathyroidectomy in patients with PHPT. There was no difference in parameters of insulin secretion before and after parathyroidectomy in patients with PHPT.
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