Abstract-Wireless sensor networks are appearing as an emerging need for mankind. Though, Such networks are still in research phase however, they have high potential to be applied in almost every field of life. Lots of research is done and a lot more is awaiting to be standardized. In this work, cluster based routing in wireless sensor networks is studied precisely. Further, we modify one of the most prominent wireless sensor network's routing protocol "LEACH" as modified LEACH (MODLEACH) by introducing efficient cluster head replacement scheme and dual transmitting power levels. Our modified LEACH, in comparison with LEACH out performs it using metrics of cluster head formation, through put and network life. Afterwards, hard and soft thresholds are implemented on modified LEACH (MODLEACH) that boast the performance even more. Finally a brief performance analysis of LEACH, Modified LEACH (MODLEACH), MODLEACH with hard threshold (MODLEACHHT) and MODLEACH with soft threshold (MODLEACHST) is undertaken considering metrics of throughput, network life and cluster head replacements.

Abstract:In this work, we propose a Realistic Scheduling Mechanism (RSM) to reduce user frustration and enhance appliance utility by classifying appliances with respective constraints and their time of use effectively. Algorithms are proposed regarding functioning of home appliances. A 24 hour time slot is divided into four logical sub-time slots, each composed of 360 min or 6 h. In these sub-time slots, only desired appliances (with respect to appliance classification) are scheduled to raise appliance utility, restricting power consumption by a dynamically modelled power usage limiter that does not only take the electricity consumer into account but also the electricity supplier. Once appliance, time and power usage limiter modelling is done, we use a nature-inspired heuristic algorithm, Binary Particle Swarm Optimization (BPSO), optimally to form schedules with given constraints representing each sub-time slot. These schedules tend to achieve an equilibrium amongst appliance utility and cost effectiveness. For validation of the proposed RSM, we provide a comparative analysis amongst unscheduled electrical load usage, scheduled directly by BPSO and RSM, reflecting user comfort, which is based upon cost effectiveness and appliance utility.

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Wireless Body Area Networks (WBANs) are in the spotlight of researchers and engineering industries due to many applications. Remote health monitoring for general as well as military purposes where tiny sensors are attached or implanted inside the skin of the body to sense the required attribute is particularly prominent. To seamlessly accomplish this procedure, there are various challenges, out of which temperature control to reduce thermal effects and optimum power consumption to reduce energy wastage are placed at the highest priority. Regular and consistent operation of a sensor node for a long-time result in a rising of the temperature of respective tissues, where it is attached or implanted. This temperature rise has harmful effects on human tissues, which may lead to the tissue damage. In this paper, a Temperate Aware and Energy Optimized (TAEO) routing protocol is proposed that not only deals with the thermal aspects and hot spot problem, but also extends the stability and lifetime of a network. Analytical simulations are conducted, and the results depict better performance in terms of the network lifetime, throughput, energy preservation, and temperature control with respect to state of the art WBAN protocols.

Precursor B cell acute lymphoblastic leukemia (B-ALL) is caused by genetic lesions in developing B cells that function as drivers for accumulation of additional mutations in an evolutionary selection process. We investigated secondary drivers of leukemogenesis in a mouse model of B-ALL driven by PU.1/Spi-B deletion (Mb1-CreΔPB). Whole exome sequencing analysis revealed recurrent mutations in Jak3 (encoding Janus Kinase 3), Jak1, and Ikzf3 (encoding Aiolos). Mutations with high variant allele frequency (VAF) were dominated by C->T transition mutations that were compatible with Activation-induced Cytidine Deaminase, whereas the majority of mutations, with low VAF, were dominated by C->A transversions associated with 8-oxoguanine DNA damage caused by reactive oxygen species (ROS). The JAK inhibitor Ruxolitinib delayed leukemia onset, reduced ROS and ROS-induced gene expression signatures, and altered ROS-induced mutational signatures. These results reveal that JAK mutations can alter the course of leukemia clonal evolution through ROS-induced DNA damage.