The carcinogenicity of several groups of carcinogens is evoked with particular reference to Dibenzo(c,g)carbazole derivatives. The activity of these derivatives is discussed with respect to their species and organ specificity. The enzymatic equipment is decisive as to whether the compounds formed can react with DNA or are simply detoxified and eliminated. All these carcinogens are complete carcinogens, i.e. they have the property of both initiation and promotion.
5,9-Dimethyl dibenzo[c,g]carbazole (5,9-diMe DBC) is a powerful organ-specific liver carcinogen in mice. Its binding to liver cytosolic proteins has been studied in vivo and in vitro with the aid of a tritium-labelled sample. Only two classes of proteins fractionated on Sephadex G100 appear to be involved in this binding: one class of high mol. wt. proteins (greater than 100 000) and another of around 45 000. The latter class contains all the glutathione-S-transferase activity (GST). The bound radioactivity has been determined after incubation in the presence or absence of microsomes. The in vivo binding has been investigated as a function of time. A highly significant covalent and noncovalent binding of 5,9-diMe DBC mostly to GST has been observed after metabolic activation.
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