The Casimir effect is investigated in light-cone quantization. It is shown that for spacelike separation of the walls enclosing the system the standard result for the pressure exerted on the walls is obtained. For walls separated in light-cone space direction no regularization of the quantum fluctuations exists which would yield a finite pressure. The origin of this failure and its implications for other vacuum properties are discussed by analyzing the Casimir effect as seen from a moving observer approaching the speed of light. The possibility for calculation of thermodynamic quantities in light-cone quantization via the Casimir effect is pointed out.
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