The finding, in the "Archivio di Stato" of Napoli, of the only surviving Justitiae register belonging to the "Cancelleria aragonese" serie 's (1453-1454), led to insight into the Calabria society thruough the analysis of the denunciations of crimes, such as: crimes against government, administration or people and sexuals crimes.
ringraziare i professori Laura Sciascia, Salvatore Fodale, per avere incoraggiato e seguito da vicino la stesura di questo lavoro. Ringrazio inoltre la professoressa Patrizia Sardina che mi ha aiutato nella traduzione dall'italiano all'inglese. DANIELA SANTORO Università di PalermoRiassunto: Partendo dal ritrovamento, presso l'Archivio di Stato di Palermo, di un inventario di beni confiscati a Manfredi Alagona nel 1393, il lavoro ricostruisce il percorso del tesoro delle regine siciliane (Costanza d'Aragona, Maria di Sicilia) che era stato incamerato dagli Alagona, potente famiglia di origine aragonese trapiantata in Sicilia. Uno studio dettagliato degli oggetti inventariati permette l'analisi di vari aspetti legati al costume e alla società s u l f i n i r e d e l X I V s e c o l o , dall'abbigliamento alla tavola, dal gusto e la moda del tempo alla cura della persona, dalla passione per i gioielli al culto per le reliquie.Parole chiave: inventario, regine, tesoro, gioielli, costume, arredamento, reliquie. Abstract:Beginning from the discovery, in the "Archivio di Stato" of Palermo, of an inventory containing the belongings confiscated from Manfredi Alagona in 1393, this work reconstructs the story of the treasure of the Sicilian queens (Costanza of Aragon and Maria of Sicily), that had been confiscated from the powerful Alagona family, originally from Aragon, who moved to Sicily. A detailed study of the inventoried movables allows the analysis of several aspects connected to customs and society at the end of the XIV th century, from clothing to utensils, from taste and fashion to care of appearance, from the love of jewels to the workship of relics.
Isotretinoin (ISO) is a synthetic analog of vitamin A. Notwithstanding the well-known long-term efficacy in the treatment of severe resistant cystic acne, ISO induces several side effects too. Dyslipidemia, increased liver enzymes, as well as reduction of biotidinase have been already reported [1]. Homocysteine (HCY), a sulfur-containing amino acid, is recycled into methionine by a transmethylation reaction requiring folate and vitamin B12. Given that during ISO treatment elevated liver enzymes (SGOT, SGPT) are often observed, it has been hypothesized that iatrogenic liver dysfunction could affect cystathionine-b-synthase, an enzyme involved in HCY metabolism, [2]. Several studies have highlighted that elevated plasma HCY concentrations are associated with an increased risk of premature occlusive vascular disease. We hereby report a case of drug-induced kidney infarction after ISO therapy. A previously healthy 18-year-old male, on therapy with 40 mg/die isotretinoin for acne, was admitted to the Emergency Unit for abdominal pain, nausea and vomiting and dyspnea. A trans-thoracic echocardiogram showed dilated and hypocontractile left ventricle. During the hospitalization he had a total body CT that showed the presence of an ischemic lesion on left kidney without other pathological findings. He started therapy with 12 IU/kg UFH as soon as a surgical emergency was excluded. Subsequently, he underwent a coronary angiogram that resulted unremarkable. Cardiac MRI showed extensive delayed gadolinium late enhancement with intramural linear pattern. In the hypothesis of drug-induced vasculitis, an extensive serological testing was performed. Elevation of serum liver enzymes (SGOT, SGPT), CRP, LDH was found. Mutations on MTHFR gene and Leiden Factor were not detected, neither alteration in coagulation parameters. Finally the dosage of plasmatic HCY resulted over the range of normality and ISO was discontinued. The patient was discharged on optimized medical therapy for heart failure. He is currently managed as outpatient. HCY levels could be found elevated in patients with ischemic events during ISO treatment. Given the widespread use of this drug for acne, it could be reasonable to dose HCY in patients with suspected liver dysfunction. Physicians should be aware of this scenario and should act swiftly to avoid uneventful outcomes. [1] Schulpis KH et al. Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne. Int J Dermatol. 2001 Jan;40(1):33-6. [2] Polat M, et al. Plasma homocysteine level is elevated in patients on isotretinoin therapy for cystic acne: a prospective controlled study. J Dermatolog Treat. 2008;19(4):229-32.
Riassunto: Mangiare e curarsi sono due dimensioni fortemente connesse al corpo, tra bisogno e piacere. Due dimensioni dense di sfumature sociali e locali, religiose ed economiche, che implicano conoscenze e terapie diverse a seconda dell'età e del sesso ma soprattutto del ruolo sociale. Con un'attenzione particolare a corti (signorili, vescovili, reali) e città, il lavoro focalizza metodi, usi e pratiche curative e alimentari di sovrani e isolani.Parole chiave: salute; alimentazione; terapia; rimedi; ricreazione; monarchia; popolo; Sicilia medievale.Abstract: Dining and personal health care are two dimensions which are strongly connected to the body, between need and pleasure. They are two dimensions which have many social, local, religious and economic implications involving knowledge and different therapies related to age and gender. The social role is equally important. With a focus on the court (noble, episcopal, real) and the cities, the present work focuses on the methods and the uses of healing practices of both kings and islanders.
Rationale and Aim of the Study Cardiac involvement is very common in transfusion dependent beta-thalassemia (TDT) and is mainly related to cardiac iron overload and myocardial damage with progressive systolic and diastolic dysfunction of the left and right ventricles. It has also been observed that in patients with TDT, cardiac fibrosis may not be directly related with iron deposition and is associated with a higher risk of cardiovascular complications. CMR is the gold standard for the evaluation of iron overload with T2* sequences and for the detection of cardiac fibrosis with late gadolinium enhancement (LGE) Apart from the use of imaging techniques, it is well known that the fibrosis and inflammation biomarkers, Galectin-3 (Gal-3) and ST2, are involved in the early stages and progression of various fibrosis-related diseases, such as heart failure, liver cirrhosis, renal and pulmonary fibrosis. To date, the role of Gal-3 and ST-2 as markers of cardiac fibrosis and myocardial damage and their possible association with myocardial damage detected by CMR, has never been studied in patients with TDT. The aim of the study was to evaluate the role of Gal-3 and ST-2 in the characterization of myocardial involvement, especially cardiac fibrosis in a population of TDT patients. Methods Twenty-six patients with a confirmed diagnosis of TDT, based on βglobin genotype, transfusion history and clinical evaluation, undergoing periodic blood transfusion and iron-chelation therapy were enrolled. None presented overt clinical signs of heart failure, CMR with T2* technique, haematochemical routine, ferritinemia assay, Gal-3 and ST-2 assay and dynamic ECG Holter were performed on all patients. Results Both Gal-3 and ST-2 have a positive correlation with systemic markers of inflammation, such as erythrocyte sedimentation rate (ESR) (10 0.65 p 0.042 and 26 0.58 p 0.002, respectively). A Gal-3 value > 17.9 ng/mL is associated with inflammatory comorbidities such as diabetes (p 0.010) and with cardiac iron overload evaluated using CMR T2 * technique (p 0.007) (Fig.1). A positive correlation was also observed with medium values of ferritine (rho 0.46 p 0.017). There was a statistically significant positive association between an ST-2 value > 35 ng/mL and cardiac fibrosis detected by CMR (p 0.020) (Fig. 2). Higher ST-2 values have been detected in patients with cardiac fibrosis when compared to those without (42 ± 14 vs 28 ±8 p 0.006). Conclusions The present study demonstrates that, in a small population of TDT patients undergoing periodic blood transfusion and iron-chelation therapy with no overt clinical signs of heart failure, Gal-3 appears to be a marker of cardiac iron overload detected with CMR T2* sequences and systemic inflammation associated with higher ESR values and inflammatory comorbidities such as diabetes mellitus. ST-2 is a marker of cardiac fibrosis detected by CMR LGE.
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