Aim The partition of the geographical variation in Argentinian terrestrial mammal species richness (SR) into environmentally, human and spatially induced variation.Location Argentina, using the twenty-three administrative provinces as the geographical units. MethodsWe recorded the number of terrestrial mammal species in each Argentinian province, and the number of species belonging to particular groups (Marsupialia, Placentaria, and among the latter, Xenarthra, Carnivora, Ungulates and Rodentia). We performed multiple regressions of each group's SR on environmental, human and spatial variables, to determine the amounts of variation explained by these factors. We then used a variance partitioning procedure to specify which proportion of the variation in SR is explained by each of the three factors exclusively and which proportions are attributable to interactions between factors.Results For marsupials, human activity explains the greatest part of the variation in SR. The purely environmental and purely human influences on all mammal SR explain a similarly high proportion of the variation in SR, whereas the purely spatial influence accounts for a smaller proportion of it. The exclusive interaction between human activity and space is negative in carnivores and rodents. For rodents, the interaction between environment and spatial situation is also negative. In the remaining placental groups, pure spatial autocorrelation explains a small proportion of the variation in SR.Main conclusions Environmental factors explain most of the variation in placental SR, while Marsupials seem to be mainly affected by human activity. However, for edentates, carnivores, and ungulates the pure human influence is more important than the pure spatial and environmental influences. Besides, human activity disrupts the spatial structure caused by the history and population dynamics of rodents and, to a lesser extent, of carnivores. The historical events and population dynamics on the one hand, and the environment on the other, cause rodent SR to vary in divergent directions. In the remaining placental groups the autocorrelation in SR is mainly the result of autocorrelation in the environmental and human variables.